Multiple Dissociations Between Comorbid Depression and Anxiety on Reward and Punishment Processing: Evidence From Computationally Informed EEG
In this report, we provide the first evidence that mood and anxiety dimensions are associated with unique aspects of EEG responses to reward and punishment, respectively. We reanalyzed data from our prior publication of a categorical depiction of depression to address more sophisticated dimensional...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ubiquity Press
2019-01-01
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| Series: | Computational Psychiatry |
| Subjects: | |
| Online Access: | https://cpsyjournal.org/articles/49 |
| _version_ | 1818066421693808640 |
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| author | James F. Cavanagh Andrew W. Bismark Michael J. Frank John J. B. Allen |
| author_facet | James F. Cavanagh Andrew W. Bismark Michael J. Frank John J. B. Allen |
| author_sort | James F. Cavanagh |
| collection | DOAJ |
| description | In this report, we provide the first evidence that mood and anxiety dimensions are associated with unique aspects of EEG responses to reward and punishment, respectively. We reanalyzed data from our prior publication of a categorical depiction of depression to address more sophisticated dimensional hypotheses. Highly symptomatic depressed individuals ('N' = 46) completed a probabilistic learning task with concurrent EEG. Measures of anxiety and depression symptomatology were significantly correlated with each other; however, only anxiety predicted better avoidance learning due to a tighter coupling of negative prediction error signaling with punishment-specific EEG features. In contrast, depression predicted a smaller reward-related EEG feature, but this did not affect prediction error coupling or the ability to learn from reward. We suggest that this reward-related alteration reflects motivational or hedonic aspects of reward and not a diminishment in the ability to represent the information content of reinforcements. These findings compel further research into the domain-specific neural systems underlying dimensional aspects of psychiatric disease. |
| first_indexed | 2024-12-10T15:07:31Z |
| format | Article |
| id | doaj.art-3cd12985185e4998abacd55d5f5be038 |
| institution | Directory Open Access Journal |
| issn | 2379-6227 |
| language | English |
| last_indexed | 2024-12-10T15:07:31Z |
| publishDate | 2019-01-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Computational Psychiatry |
| spelling | doaj.art-3cd12985185e4998abacd55d5f5be0382022-12-22T01:44:00ZengUbiquity PressComputational Psychiatry2379-62272019-01-01311710.1162/CPSY_a_0002447Multiple Dissociations Between Comorbid Depression and Anxiety on Reward and Punishment Processing: Evidence From Computationally Informed EEGJames F. Cavanagh0Andrew W. Bismark1Michael J. Frank2John J. B. Allen3Department of Psychology, University of New Mexico, Albuquerque, New MexicoVA San Diego Healthcare System, San Diego, CaliforniaDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, Rhode IslandDepartment of Psychology, University of Arizona, Tucson, ArizonaIn this report, we provide the first evidence that mood and anxiety dimensions are associated with unique aspects of EEG responses to reward and punishment, respectively. We reanalyzed data from our prior publication of a categorical depiction of depression to address more sophisticated dimensional hypotheses. Highly symptomatic depressed individuals ('N' = 46) completed a probabilistic learning task with concurrent EEG. Measures of anxiety and depression symptomatology were significantly correlated with each other; however, only anxiety predicted better avoidance learning due to a tighter coupling of negative prediction error signaling with punishment-specific EEG features. In contrast, depression predicted a smaller reward-related EEG feature, but this did not affect prediction error coupling or the ability to learn from reward. We suggest that this reward-related alteration reflects motivational or hedonic aspects of reward and not a diminishment in the ability to represent the information content of reinforcements. These findings compel further research into the domain-specific neural systems underlying dimensional aspects of psychiatric disease.https://cpsyjournal.org/articles/49depressionanxietyfrnrew-preinforcement learningcomputational psychiatry |
| spellingShingle | James F. Cavanagh Andrew W. Bismark Michael J. Frank John J. B. Allen Multiple Dissociations Between Comorbid Depression and Anxiety on Reward and Punishment Processing: Evidence From Computationally Informed EEG Computational Psychiatry depression anxiety frn rew-p reinforcement learning computational psychiatry |
| title | Multiple Dissociations Between Comorbid Depression and Anxiety on Reward and Punishment Processing: Evidence From Computationally Informed EEG |
| title_full | Multiple Dissociations Between Comorbid Depression and Anxiety on Reward and Punishment Processing: Evidence From Computationally Informed EEG |
| title_fullStr | Multiple Dissociations Between Comorbid Depression and Anxiety on Reward and Punishment Processing: Evidence From Computationally Informed EEG |
| title_full_unstemmed | Multiple Dissociations Between Comorbid Depression and Anxiety on Reward and Punishment Processing: Evidence From Computationally Informed EEG |
| title_short | Multiple Dissociations Between Comorbid Depression and Anxiety on Reward and Punishment Processing: Evidence From Computationally Informed EEG |
| title_sort | multiple dissociations between comorbid depression and anxiety on reward and punishment processing evidence from computationally informed eeg |
| topic | depression anxiety frn rew-p reinforcement learning computational psychiatry |
| url | https://cpsyjournal.org/articles/49 |
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