ncRNA-mediated overexpression of ubiquitin-specific proteinase 13 contributes to the progression of prostate cancer via modulating AR signaling, DNA damage repair and immune infiltration

ncRNA-mediated overexpression of ubiquitin-specific proteinase 13 contributes to the progression of prostate cancer via modulating AR signaling, DNA damage repair and immune infiltration

Abstract Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of prostate cancer, and the molecular mechanism driving mCRPC progression has not yet been fully elucidated. Immunotherapies such as chimeric antigen receptor, T-cell therapy and immune checkpoint blockade have exerted...

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Bibliographic Details
Main Authors: Xiaolu Cui, Hongyuan Yu, Jinlong Yao, Jinling Li, Zhenhua Li, Zhenming Jiang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Cancer
Subjects:
Prostate cancer
Deubiquitinase
Immunotherapy
DNA damage response
AR signaling
ceRNA
Online Access:https://doi.org/10.1186/s12885-022-10424-7

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