Admission Lysophosphatidic Acid Is Related to Impaired Kidney Function in Acute Aortic Dissection: 2-Year Retrospective Follow-Up Study
BackgroundDelayed treatment of acute aortic dissection (AAD)-related acute kidney injury (AKI) significantly increases the burden of chronic kidney disease (CKD) and mortality. Lysophosphatidic acid (LPA) is a shared mediator of kidney disease and AAD. Here, we evaluated the relationship between LPA...
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| Format: | Article |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.905406/full |
| _version_ | 1818231668377387008 |
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| author | Xiaogao Pan Xiaogao Pan Guifang Yang Guifang Yang Ning Ding Wen Peng Wen Peng Tuo Guo Tuo Guo Mengping Zeng Mengping Zeng Xiangping Chai Xiangping Chai |
| author_facet | Xiaogao Pan Xiaogao Pan Guifang Yang Guifang Yang Ning Ding Wen Peng Wen Peng Tuo Guo Tuo Guo Mengping Zeng Mengping Zeng Xiangping Chai Xiangping Chai |
| author_sort | Xiaogao Pan |
| collection | DOAJ |
| description | BackgroundDelayed treatment of acute aortic dissection (AAD)-related acute kidney injury (AKI) significantly increases the burden of chronic kidney disease (CKD) and mortality. Lysophosphatidic acid (LPA) is a shared mediator of kidney disease and AAD. Here, we evaluated the relationship between LPA and kidney injury in AAD patients.MethodsWe measured the plasma concentration of LPA in a cohort of 80 patients with AAD. Least Absolute Shrinkage and Selection Operator (LASSO) regression and Logistic regression were used to evaluate the effect and interaction of LPA on AKI. Additive generalized model and penalized spline method were used to describe the non-linear association. Multivariable analyses with the Cox proportional-hazards model were used for subgroup analysis and interaction in LPA and subsequent CKD.ResultsThe participant’s average age was 54.27 ± 11.00 years, 68.75% of them were males, and the incidence of AKI was 43.75%. Patients with AKI had higher levels of LPA on admission, and the more significant the increase, the higher the risk of AKI. There was a non-linear positive correlation between admission LPA and AKI, and the premeditated inflection point was 346.33 (μg/dL) through two-piecewise linear regression and recursive algorithm. Subgroup analysis identified a stronger association between admission LPA and AKI in the elder, female and medically treated patients. The incidence of CKD was 22.67% in the 2-year follow-up. Patients with subsequent CKD had higher LPA levels on admission in the follow-up cohort, and a similar interaction trend was also observed through Cox proportional—hazards model.ConclusionAdmission LPA levels show a non-linear positive correlation with AKI and increase the risk of subsequent CKD, which is more pronounced in elderly, female, and medically treated patients. |
| first_indexed | 2024-12-12T10:54:03Z |
| format | Article |
| id | doaj.art-3cd17816c45148338c6aad23be0455e0 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-12T10:54:03Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-3cd17816c45148338c6aad23be0455e02022-12-22T00:26:43ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-06-01910.3389/fcvm.2022.905406905406Admission Lysophosphatidic Acid Is Related to Impaired Kidney Function in Acute Aortic Dissection: 2-Year Retrospective Follow-Up StudyXiaogao Pan0Xiaogao Pan1Guifang Yang2Guifang Yang3Ning Ding4Wen Peng5Wen Peng6Tuo Guo7Tuo Guo8Mengping Zeng9Mengping Zeng10Xiangping Chai11Xiangping Chai12Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, ChinaEmergency Medicine and Difficult Diseases Institute, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, ChinaEmergency Medicine and Difficult Diseases Institute, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Emergency, Changsha Central Hospital, University of South China, Changsha, ChinaDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, ChinaEmergency Medicine and Difficult Diseases Institute, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, ChinaEmergency Medicine and Difficult Diseases Institute, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, ChinaEmergency Medicine and Difficult Diseases Institute, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, ChinaEmergency Medicine and Difficult Diseases Institute, Second Xiangya Hospital, Central South University, Changsha, ChinaBackgroundDelayed treatment of acute aortic dissection (AAD)-related acute kidney injury (AKI) significantly increases the burden of chronic kidney disease (CKD) and mortality. Lysophosphatidic acid (LPA) is a shared mediator of kidney disease and AAD. Here, we evaluated the relationship between LPA and kidney injury in AAD patients.MethodsWe measured the plasma concentration of LPA in a cohort of 80 patients with AAD. Least Absolute Shrinkage and Selection Operator (LASSO) regression and Logistic regression were used to evaluate the effect and interaction of LPA on AKI. Additive generalized model and penalized spline method were used to describe the non-linear association. Multivariable analyses with the Cox proportional-hazards model were used for subgroup analysis and interaction in LPA and subsequent CKD.ResultsThe participant’s average age was 54.27 ± 11.00 years, 68.75% of them were males, and the incidence of AKI was 43.75%. Patients with AKI had higher levels of LPA on admission, and the more significant the increase, the higher the risk of AKI. There was a non-linear positive correlation between admission LPA and AKI, and the premeditated inflection point was 346.33 (μg/dL) through two-piecewise linear regression and recursive algorithm. Subgroup analysis identified a stronger association between admission LPA and AKI in the elder, female and medically treated patients. The incidence of CKD was 22.67% in the 2-year follow-up. Patients with subsequent CKD had higher LPA levels on admission in the follow-up cohort, and a similar interaction trend was also observed through Cox proportional—hazards model.ConclusionAdmission LPA levels show a non-linear positive correlation with AKI and increase the risk of subsequent CKD, which is more pronounced in elderly, female, and medically treated patients.https://www.frontiersin.org/articles/10.3389/fcvm.2022.905406/fulllysophosphatidic acidaortic dissectionacute kidney injuryAKIchronic kidney diseaseCKD |
| spellingShingle | Xiaogao Pan Xiaogao Pan Guifang Yang Guifang Yang Ning Ding Wen Peng Wen Peng Tuo Guo Tuo Guo Mengping Zeng Mengping Zeng Xiangping Chai Xiangping Chai Admission Lysophosphatidic Acid Is Related to Impaired Kidney Function in Acute Aortic Dissection: 2-Year Retrospective Follow-Up Study Frontiers in Cardiovascular Medicine lysophosphatidic acid aortic dissection acute kidney injury AKI chronic kidney disease CKD |
| title | Admission Lysophosphatidic Acid Is Related to Impaired Kidney Function in Acute Aortic Dissection: 2-Year Retrospective Follow-Up Study |
| title_full | Admission Lysophosphatidic Acid Is Related to Impaired Kidney Function in Acute Aortic Dissection: 2-Year Retrospective Follow-Up Study |
| title_fullStr | Admission Lysophosphatidic Acid Is Related to Impaired Kidney Function in Acute Aortic Dissection: 2-Year Retrospective Follow-Up Study |
| title_full_unstemmed | Admission Lysophosphatidic Acid Is Related to Impaired Kidney Function in Acute Aortic Dissection: 2-Year Retrospective Follow-Up Study |
| title_short | Admission Lysophosphatidic Acid Is Related to Impaired Kidney Function in Acute Aortic Dissection: 2-Year Retrospective Follow-Up Study |
| title_sort | admission lysophosphatidic acid is related to impaired kidney function in acute aortic dissection 2 year retrospective follow up study |
| topic | lysophosphatidic acid aortic dissection acute kidney injury AKI chronic kidney disease CKD |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.905406/full |
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