Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy. The activity of mTORC1 is dynamically regulated by several environmental cues, including...

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Bibliographic Details
Main Authors: Terunao Takahara, Yuna Amemiya, Risa Sugiyama, Masatoshi Maki, Hideki Shibata
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Biomedical Science
Subjects:
mTOR
mTORC1
Amino acids
Rag GTPases
Rheb GTPase
Intracellular Ca2+ concentration
Online Access:http://link.springer.com/article/10.1186/s12929-020-00679-2

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