Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial
There is little information on pulmonary rehabilitation in patients with cystic fibrosis (CF) with pulmonary exacerbation. This study aimed to evaluate the effects of an early rehabilitation program on lung function, muscle strength, inflammatory markers, and quality of life in adults with CF hospit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2023-08-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100655&lng=en&tlng=en |
| _version_ | 1797743230713856000 |
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| author | J. Flores B. Ziegler D. Silvello P.T.R. Dalcin |
| author_facet | J. Flores B. Ziegler D. Silvello P.T.R. Dalcin |
| author_sort | J. Flores |
| collection | DOAJ |
| description | There is little information on pulmonary rehabilitation in patients with cystic fibrosis (CF) with pulmonary exacerbation. This study aimed to evaluate the effects of an early rehabilitation program on lung function, muscle strength, inflammatory markers, and quality of life in adults with CF hospitalized for pulmonary exacerbation. In this randomized controlled trial, 19 patients were included in the intervention group and 15 in the control group. The intervention group underwent an early rehabilitation program for 14 days after admission. All patients underwent spirometry, one-repetition maximum tests (1RM), and the 6-min walk test, and answered the Revised Cystic Fibrosis Questionnaire (CFQ-R) for quality of life and the International Physical Activity Questionnaire. Serum levels of interleukin and tumor necrosis factor alpha (TNF-α) were measured. In the intervention group, there were increases in 1RM biceps (P=0.009), triceps (P=0.005), shoulder abductors (P=0.002), shoulder flexors (P=0.004), hamstrings (P<0.001), and quadriceps values (P<0.001). In addition, there were improvements in CFQ-R-emotion (P=0.002), treatment burden (P=0.002), vitality (P=0.011), and physical scores (P=0.026), and a reduction in the Borg resting fatigue score (P=0.037). The interleukins levels did not change after the intervention. In adult CF patients with pulmonary exacerbation, early hospital rehabilitation had a significant impact on improving resting fatigue, muscle strength, and quality of life. |
| first_indexed | 2024-03-12T14:52:33Z |
| format | Article |
| id | doaj.art-3cd20bdf56b74dfd949722df66509e03 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-03-12T14:52:33Z |
| publishDate | 2023-08-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-3cd20bdf56b74dfd949722df66509e032023-08-15T07:47:53ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2023-08-015610.1590/1414-431x2023e12752Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trialJ. Floreshttps://orcid.org/0000-0002-9925-0119B. Zieglerhttps://orcid.org/0000-0001-7177-7085D. Silvellohttps://orcid.org/0000-0002-7526-1593P.T.R. Dalcinhttps://orcid.org/0000-0002-9774-9135There is little information on pulmonary rehabilitation in patients with cystic fibrosis (CF) with pulmonary exacerbation. This study aimed to evaluate the effects of an early rehabilitation program on lung function, muscle strength, inflammatory markers, and quality of life in adults with CF hospitalized for pulmonary exacerbation. In this randomized controlled trial, 19 patients were included in the intervention group and 15 in the control group. The intervention group underwent an early rehabilitation program for 14 days after admission. All patients underwent spirometry, one-repetition maximum tests (1RM), and the 6-min walk test, and answered the Revised Cystic Fibrosis Questionnaire (CFQ-R) for quality of life and the International Physical Activity Questionnaire. Serum levels of interleukin and tumor necrosis factor alpha (TNF-α) were measured. In the intervention group, there were increases in 1RM biceps (P=0.009), triceps (P=0.005), shoulder abductors (P=0.002), shoulder flexors (P=0.004), hamstrings (P<0.001), and quadriceps values (P<0.001). In addition, there were improvements in CFQ-R-emotion (P=0.002), treatment burden (P=0.002), vitality (P=0.011), and physical scores (P=0.026), and a reduction in the Borg resting fatigue score (P=0.037). The interleukins levels did not change after the intervention. In adult CF patients with pulmonary exacerbation, early hospital rehabilitation had a significant impact on improving resting fatigue, muscle strength, and quality of life.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100655&lng=en&tlng=enCystic fibrosisAdultsPhysical exercisePulmonary exacerbationHospitalization |
| spellingShingle | J. Flores B. Ziegler D. Silvello P.T.R. Dalcin Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial Brazilian Journal of Medical and Biological Research Cystic fibrosis Adults Physical exercise Pulmonary exacerbation Hospitalization |
| title | Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial |
| title_full | Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial |
| title_fullStr | Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial |
| title_full_unstemmed | Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial |
| title_short | Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial |
| title_sort | effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization a randomized clinical trial |
| topic | Cystic fibrosis Adults Physical exercise Pulmonary exacerbation Hospitalization |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100655&lng=en&tlng=en |
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