Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model
Patients with Parkinson’s disease (PD) manifest nonmotor and motor symptoms. Autonomic cardiovascular dysregulation is a common nonmotor manifestation associated with increased morbimortality. Conventional clinical treatment alleviates motor signs but does not change disease progression and fails in...
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1551 |
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| author | Valeria C. Gonçalves Daniel J. L. L. Pinheiro Tomás de la Rosa Antônio-Carlos G. de Almeida Fúlvio A. Scorza Carla A. Scorza |
| author_facet | Valeria C. Gonçalves Daniel J. L. L. Pinheiro Tomás de la Rosa Antônio-Carlos G. de Almeida Fúlvio A. Scorza Carla A. Scorza |
| author_sort | Valeria C. Gonçalves |
| collection | DOAJ |
| description | Patients with Parkinson’s disease (PD) manifest nonmotor and motor symptoms. Autonomic cardiovascular dysregulation is a common nonmotor manifestation associated with increased morbimortality. Conventional clinical treatment alleviates motor signs but does not change disease progression and fails in handling nonmotor features. Nutrition is a key modifiable determinant of chronic disease. This study aimed to assess the effects of propolis on cardiological features, heart rate (HR) and heart rate variability (HRV) and on nigrostriatal dopaminergic damage, detected by tyrosine hydroxylase (TH) immunoreactivity, in the 6-hydroxydopamine (6-OHDA) rat model of PD. Male Wistar rats were injected bilaterally with 6-OHDA or saline into the striatum and were treated with propolis or water for 40 days. Autonomic function was assessed by time domain parameters (standard deviation of all normal-to-normal intervals (SDNN) and square root of the mean of the squared differences between adjacent normal RR intervals (RMSSD)) of HRV calculated from electrocardiogram recordings. Reductions in HR (<i>p</i> = 1.47 × 10<sup>−19</sup>), SDNN (<i>p</i> = 3.42 × 10<sup>−10</sup>) and RMSSD (<i>p</i> = 8.2 × 10<sup>−6</sup>) detected in parkinsonian rats were reverted by propolis. Propolis attenuated neuronal loss in the substantia nigra (<i>p</i> = 5.66 × 10<sup>−15</sup>) and reduced striatal fiber degeneration (<i>p</i> = 7.4 × 10<sup>−5</sup>) in 6-OHDA-injured rats, which also showed significant weight gain (<i>p</i> = 1.07 × 10<sup>−5</sup>) in comparison to 6-OHDA-lesioned counterparts. Propolis confers cardioprotection and neuroprotection in the 6-OHDA rat model of PD. |
| first_indexed | 2024-03-10T19:34:31Z |
| format | Article |
| id | doaj.art-3cd26221bf0e4aa3a49646fb2d094ebc |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:34:31Z |
| publishDate | 2020-05-01 |
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| series | Nutrients |
| spelling | doaj.art-3cd26221bf0e4aa3a49646fb2d094ebc2023-11-20T01:50:25ZengMDPI AGNutrients2072-66432020-05-01126155110.3390/nu12061551Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat ModelValeria C. Gonçalves0Daniel J. L. L. Pinheiro1Tomás de la Rosa2Antônio-Carlos G. de Almeida3Fúlvio A. Scorza4Carla A. Scorza5Disciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, BrazilDisciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, BrazilDisciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, BrazilLaboratório de Neurociências Experimental e Computacional, Departamento de Engenharia de Biossistemas, Universidade Federal de São João del-Rei (UFSJ), Minas Gerais 36301-160, BrazilDisciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, BrazilDisciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, BrazilPatients with Parkinson’s disease (PD) manifest nonmotor and motor symptoms. Autonomic cardiovascular dysregulation is a common nonmotor manifestation associated with increased morbimortality. Conventional clinical treatment alleviates motor signs but does not change disease progression and fails in handling nonmotor features. Nutrition is a key modifiable determinant of chronic disease. This study aimed to assess the effects of propolis on cardiological features, heart rate (HR) and heart rate variability (HRV) and on nigrostriatal dopaminergic damage, detected by tyrosine hydroxylase (TH) immunoreactivity, in the 6-hydroxydopamine (6-OHDA) rat model of PD. Male Wistar rats were injected bilaterally with 6-OHDA or saline into the striatum and were treated with propolis or water for 40 days. Autonomic function was assessed by time domain parameters (standard deviation of all normal-to-normal intervals (SDNN) and square root of the mean of the squared differences between adjacent normal RR intervals (RMSSD)) of HRV calculated from electrocardiogram recordings. Reductions in HR (<i>p</i> = 1.47 × 10<sup>−19</sup>), SDNN (<i>p</i> = 3.42 × 10<sup>−10</sup>) and RMSSD (<i>p</i> = 8.2 × 10<sup>−6</sup>) detected in parkinsonian rats were reverted by propolis. Propolis attenuated neuronal loss in the substantia nigra (<i>p</i> = 5.66 × 10<sup>−15</sup>) and reduced striatal fiber degeneration (<i>p</i> = 7.4 × 10<sup>−5</sup>) in 6-OHDA-injured rats, which also showed significant weight gain (<i>p</i> = 1.07 × 10<sup>−5</sup>) in comparison to 6-OHDA-lesioned counterparts. Propolis confers cardioprotection and neuroprotection in the 6-OHDA rat model of PD.https://www.mdpi.com/2072-6643/12/6/1551Parkinson’s diseasepropolis6-OHDA |
| spellingShingle | Valeria C. Gonçalves Daniel J. L. L. Pinheiro Tomás de la Rosa Antônio-Carlos G. de Almeida Fúlvio A. Scorza Carla A. Scorza Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model Nutrients Parkinson’s disease propolis 6-OHDA |
| title | Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model |
| title_full | Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model |
| title_fullStr | Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model |
| title_full_unstemmed | Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model |
| title_short | Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model |
| title_sort | propolis as a potential disease modifying strategy in parkinson s disease cardioprotective and neuroprotective effects in the 6 ohda rat model |
| topic | Parkinson’s disease propolis 6-OHDA |
| url | https://www.mdpi.com/2072-6643/12/6/1551 |
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