Blocking VEGF signaling augments interleukin-8 secretion via MEK/ERK/1/2 axis in human retinal pigment epithelial cells

Blocking VEGF signaling augments interleukin-8 secretion via MEK/ERK/1/2 axis in human retinal pigment epithelial cells

AIM: To identify proangiogenic factors engaged in neovascular age-related macular degeneration (AMD) except vascular endothelial growth factor (VEGF) from human retinal pigment epithelial (hRPE) cells and investigate the underlying mechanisms. METHODS: VEGF receptor 2 (VEGFR2) in ARPE-19 cells was...

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Bibliographic Details
Main Authors:	Lin-Bin Zhou, Ye-Qi Zhou, Xin-Yu Zhang
Format:	Article
Language:	English
Published:	Press of International Journal of Ophthalmology (IJO PRESS) 2020-07-01
Series:	International Journal of Ophthalmology
Subjects:	age-related macular degeneration vascular endothelial growth factor signaling anti-vascular endothelial growth factor therapy retinal pigment epithelial cells interleukin-8
Online Access:	http://ies.ijo.cn/en_publish/2020/7/20200704.pdf

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