Weight Changes in Patients with Differentiated Thyroid Carcinoma during Postoperative Long-Term Follow-up under Thyroid Stimulating Hormone Suppression
BackgroundThere are limited data about whether patients who receive initial treatment for differentiated thyroid cancer (DTC) gain or lose weight during long-term follow-up under thyroid stimulating hormone (TSH) suppression. This study was aimed to evaluate whether DTC patients under TSH suppressio...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2015-09-01
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| Series: | Endocrinology and Metabolism |
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| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-343.pdf |
| _version_ | 1818745004737167360 |
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| author | Seo Young Sohn Ji Young Joung Yoon Young Cho Sun Mi Park Sang Man Jin Jae Hoon Chung Sun Wook Kim |
| author_facet | Seo Young Sohn Ji Young Joung Yoon Young Cho Sun Mi Park Sang Man Jin Jae Hoon Chung Sun Wook Kim |
| author_sort | Seo Young Sohn |
| collection | DOAJ |
| description | BackgroundThere are limited data about whether patients who receive initial treatment for differentiated thyroid cancer (DTC) gain or lose weight during long-term follow-up under thyroid stimulating hormone (TSH) suppression. This study was aimed to evaluate whether DTC patients under TSH suppression experience long-term weight gain after initial treatment. We also examined the impact of the radioactive iodine ablation therapy (RAIT) preparation method on changes of weight, comparing thyroid hormone withdrawal (THW) and recombinant human TSH (rhTSH).MethodsWe retrospectively reviewed 700 DTC patients who underwent a total thyroidectomy followed by either RAIT and levothyroxine (T4) replacement or T4 replacement alone. The control group included 350 age-matched patients with benign thyroid nodules followed during same period. Anthropometric data were measured at baseline, 1 to 2 years, and 3 to 4 years after thyroidectomy. Comparisons were made between weight and body mass index (BMI) at baseline and follow-up.ResultsSignificant gains in weight and BMI were observed 3 to 4 years after initial treatment for female DTC but not in male patients. These gains among female DTC patients were also significant compared to age-matched control. Women in the THW group gained a significant amount of weight and BMI compared to baseline, while there was no increase in weight or BMI in the rhTSH group. There were no changes in weight and BMI in men according to RAIT preparation methods.ConclusionFemale DTC patients showed significant gains in weight and BMI during long-term follow-up after initial treatment. These changes were seen only in patients who underwent THW for RAIT. |
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| id | doaj.art-3cd3eeca9977426b965c1e6e67b5a6f2 |
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| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-18T02:53:19Z |
| publishDate | 2015-09-01 |
| publisher | Korean Endocrine Society |
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| series | Endocrinology and Metabolism |
| spelling | doaj.art-3cd3eeca9977426b965c1e6e67b5a6f22022-12-21T21:23:25ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782015-09-0130334335110.3803/EnM.2015.30.3.34320823Weight Changes in Patients with Differentiated Thyroid Carcinoma during Postoperative Long-Term Follow-up under Thyroid Stimulating Hormone SuppressionSeo Young SohnJi Young JoungYoon Young ChoSun Mi ParkSang Man JinJae Hoon ChungSun Wook KimBackgroundThere are limited data about whether patients who receive initial treatment for differentiated thyroid cancer (DTC) gain or lose weight during long-term follow-up under thyroid stimulating hormone (TSH) suppression. This study was aimed to evaluate whether DTC patients under TSH suppression experience long-term weight gain after initial treatment. We also examined the impact of the radioactive iodine ablation therapy (RAIT) preparation method on changes of weight, comparing thyroid hormone withdrawal (THW) and recombinant human TSH (rhTSH).MethodsWe retrospectively reviewed 700 DTC patients who underwent a total thyroidectomy followed by either RAIT and levothyroxine (T4) replacement or T4 replacement alone. The control group included 350 age-matched patients with benign thyroid nodules followed during same period. Anthropometric data were measured at baseline, 1 to 2 years, and 3 to 4 years after thyroidectomy. Comparisons were made between weight and body mass index (BMI) at baseline and follow-up.ResultsSignificant gains in weight and BMI were observed 3 to 4 years after initial treatment for female DTC but not in male patients. These gains among female DTC patients were also significant compared to age-matched control. Women in the THW group gained a significant amount of weight and BMI compared to baseline, while there was no increase in weight or BMI in the rhTSH group. There were no changes in weight and BMI in men according to RAIT preparation methods.ConclusionFemale DTC patients showed significant gains in weight and BMI during long-term follow-up after initial treatment. These changes were seen only in patients who underwent THW for RAIT.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-343.pdfThyroid neoplasmsBody weightThyroid hormonesThyrotropin |
| spellingShingle | Seo Young Sohn Ji Young Joung Yoon Young Cho Sun Mi Park Sang Man Jin Jae Hoon Chung Sun Wook Kim Weight Changes in Patients with Differentiated Thyroid Carcinoma during Postoperative Long-Term Follow-up under Thyroid Stimulating Hormone Suppression Endocrinology and Metabolism Thyroid neoplasms Body weight Thyroid hormones Thyrotropin |
| title | Weight Changes in Patients with Differentiated Thyroid Carcinoma during Postoperative Long-Term Follow-up under Thyroid Stimulating Hormone Suppression |
| title_full | Weight Changes in Patients with Differentiated Thyroid Carcinoma during Postoperative Long-Term Follow-up under Thyroid Stimulating Hormone Suppression |
| title_fullStr | Weight Changes in Patients with Differentiated Thyroid Carcinoma during Postoperative Long-Term Follow-up under Thyroid Stimulating Hormone Suppression |
| title_full_unstemmed | Weight Changes in Patients with Differentiated Thyroid Carcinoma during Postoperative Long-Term Follow-up under Thyroid Stimulating Hormone Suppression |
| title_short | Weight Changes in Patients with Differentiated Thyroid Carcinoma during Postoperative Long-Term Follow-up under Thyroid Stimulating Hormone Suppression |
| title_sort | weight changes in patients with differentiated thyroid carcinoma during postoperative long term follow up under thyroid stimulating hormone suppression |
| topic | Thyroid neoplasms Body weight Thyroid hormones Thyrotropin |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-343.pdf |
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