Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis
Objective: This is a prospective, randomized study designed to demonstrate the efficacy of three study drugs (Levosulpiride, Domperidone and Metoclopramide) in Functional Dyspepsia. Subject recruitment was done from medicine outpatient department of the teaching hospital from June 2013 to Novemb...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5775/11613_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG)_u.pdf |
| Summary: | Objective: This is a prospective, randomized study designed
to demonstrate the efficacy of three study drugs (Levosulpiride,
Domperidone and Metoclopramide) in Functional Dyspepsia.
Subject recruitment was done from medicine outpatient department
of the teaching hospital from June 2013 to November 2013.
Materials and Methods: The data collection was performed by the
Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), a question
instrument for assessing the dyspeptic symptoms of functional
dyspepsia in patients enrolled for the study. The symptoms were
assessed at base line (Prior to initiation of therapy) and at 4 weeks,
on a 5-point scale.
Result: Among 120 patients 113 patients completed this study in
three groups (G-1 Levosulpiride 40 patients, G-2 Domperidone 35
patients and G-3 Metoclopramide 38 patients) were followed up.
Female gender dominated (75), occupation wise most of patients
belonged to labour class (49). Highly significant improvement in
symptoms scale was noticed in G-1 Levosulpiride 40 patients’
group.
Conclusion: Functional Gastrointestinal disorders are not
serious ailments but have a key impact on quality of life. Overall
dyspeptic symptom relief rates were significantly high in the
Levosulpiride group (p<0.004) as compared to Domperidone
and Metoclopramide groups. A proper understanding of disease
process by health care personnel and by sufferer is obligatory to
enhance the quality of life and daunt the self/over the counter
medication in this condition. |
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| ISSN: | 2249-782X 0973-709X |