Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis
Objective: This is a prospective, randomized study designed to demonstrate the efficacy of three study drugs (Levosulpiride, Domperidone and Metoclopramide) in Functional Dyspepsia. Subject recruitment was done from medicine outpatient department of the teaching hospital from June 2013 to Novemb...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5775/11613_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG)_u.pdf |
| _version_ | 1818883450945404928 |
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| author | Harminder Singh Ritu Bala Kamalpreet Kaur |
| author_facet | Harminder Singh Ritu Bala Kamalpreet Kaur |
| author_sort | Harminder Singh |
| collection | DOAJ |
| description | Objective: This is a prospective, randomized study designed
to demonstrate the efficacy of three study drugs (Levosulpiride,
Domperidone and Metoclopramide) in Functional Dyspepsia.
Subject recruitment was done from medicine outpatient department
of the teaching hospital from June 2013 to November 2013.
Materials and Methods: The data collection was performed by the
Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), a question
instrument for assessing the dyspeptic symptoms of functional
dyspepsia in patients enrolled for the study. The symptoms were
assessed at base line (Prior to initiation of therapy) and at 4 weeks,
on a 5-point scale.
Result: Among 120 patients 113 patients completed this study in
three groups (G-1 Levosulpiride 40 patients, G-2 Domperidone 35
patients and G-3 Metoclopramide 38 patients) were followed up.
Female gender dominated (75), occupation wise most of patients
belonged to labour class (49). Highly significant improvement in
symptoms scale was noticed in G-1 Levosulpiride 40 patients’
group.
Conclusion: Functional Gastrointestinal disorders are not
serious ailments but have a key impact on quality of life. Overall
dyspeptic symptom relief rates were significantly high in the
Levosulpiride group (p<0.004) as compared to Domperidone
and Metoclopramide groups. A proper understanding of disease
process by health care personnel and by sufferer is obligatory to
enhance the quality of life and daunt the self/over the counter
medication in this condition. |
| first_indexed | 2024-12-19T15:33:51Z |
| format | Article |
| id | doaj.art-3cd854f60ddd4389ba87e1d1d9870b70 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-19T15:33:51Z |
| publishDate | 2015-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-3cd854f60ddd4389ba87e1d1d9870b702022-12-21T20:15:40ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-04-0194FC09FC1210.7860/JCDR/2015/11613.5775Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative AnalysisHarminder Singh0Ritu Bala1Kamalpreet Kaur2Associate Professor, Department of Pharmacology, G.G.S. Medical College, Faridkot, Punjab, India.3nd year Post-graduate Resident, Department of Pharmacology, G.G.S. Medical College, Faridkot, Punjab, India.Assistant Professor, Department of Pharmacology, G.G.S. Medical College, Faridkot, Punjab, India.Objective: This is a prospective, randomized study designed to demonstrate the efficacy of three study drugs (Levosulpiride, Domperidone and Metoclopramide) in Functional Dyspepsia. Subject recruitment was done from medicine outpatient department of the teaching hospital from June 2013 to November 2013. Materials and Methods: The data collection was performed by the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), a question instrument for assessing the dyspeptic symptoms of functional dyspepsia in patients enrolled for the study. The symptoms were assessed at base line (Prior to initiation of therapy) and at 4 weeks, on a 5-point scale. Result: Among 120 patients 113 patients completed this study in three groups (G-1 Levosulpiride 40 patients, G-2 Domperidone 35 patients and G-3 Metoclopramide 38 patients) were followed up. Female gender dominated (75), occupation wise most of patients belonged to labour class (49). Highly significant improvement in symptoms scale was noticed in G-1 Levosulpiride 40 patients’ group. Conclusion: Functional Gastrointestinal disorders are not serious ailments but have a key impact on quality of life. Overall dyspeptic symptom relief rates were significantly high in the Levosulpiride group (p<0.004) as compared to Domperidone and Metoclopramide groups. A proper understanding of disease process by health care personnel and by sufferer is obligatory to enhance the quality of life and daunt the self/over the counter medication in this condition.https://jcdr.net/articles/PDF/5775/11613_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG)_u.pdfgastrointestinal disordersprokineticquality of life |
| spellingShingle | Harminder Singh Ritu Bala Kamalpreet Kaur Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis Journal of Clinical and Diagnostic Research gastrointestinal disorders prokinetic quality of life |
| title | Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis |
| title_full | Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis |
| title_fullStr | Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis |
| title_full_unstemmed | Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis |
| title_short | Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis |
| title_sort | efficacy and tolerability of levosulpiride domperidone and metoclopramide in patients with non ulcer functional dyspepsia a comparative analysis |
| topic | gastrointestinal disorders prokinetic quality of life |
| url | https://jcdr.net/articles/PDF/5775/11613_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG)_u.pdf |
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