∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem‐like cells in human ER+ and HER2+ breast cancers

∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem‐like cells in human ER+ and HER2+ breast cancers

Abstract ΔNp63, also known as p40, regulates stemness of normal mammary gland epithelium and provides stem cell characteristics in basal and HER2‐driven murine breast cancer models. Whilst ΔNp63/p40 is a characteristic feature of normal basal cells and basal‐type triple‐negative breast cancer, some...

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Bibliographic Details
Main Authors: Yajing Liu, Marta Nekulova, Rudolf Nenutil, Iva Horakova, M Virginia Appleyard, Karen Murray, Jitka Holcakova, Michaela Galoczova, Philip Quinlan, Lee B Jordan, Colin A Purdie, Borivoj Vojtesek, Alastair M Thompson, Philip J Coates
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:The Journal of Pathology: Clinical Research
Subjects:
p63
ΔNp63
p40
breast
cancer stem cells
oestrogen receptor
Online Access:https://doi.org/10.1002/cjp2.149

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