Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma

Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma

Charcot-Leyden crystals (CLCs) are the hallmark of many eosinophilic-based diseases, such as asthma. Here, we report that reduced glutathione (GSH) disrupts CLCs and inhibits crystallization of human galectin-10 (Gal-10). GSH has no effect on CLCs from monkeys ( Macaca fascicular...

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Bibliographic Details
Main Authors: Na Heya, Sayed Hend, Ayala Gabriela Jaramillo, Wang Xing, Liu Yuhan, Yu Jinyi, Liu Tianhao, Mayo Kevin H., Su Jiyong
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-03-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
asthma
Charcot-Leyden crystal
glutathione
galectin-10
tubulin α-1B
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023050

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