Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight
Abstract Background Cadmium (Cd), lead (Pb) and arsenic (As) are common environmental contaminants that have been associated with lower birthweight. Although some essential metals may mitigate exposure, data are inconsistent. This study sought to evaluate the relationship between toxic metals, nutri...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-04-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12889-017-4225-8 |
| _version_ | 1818515763690995712 |
|---|---|
| author | Yiwen Luo Lauren E. McCullough Jung-Ying Tzeng Thomas Darrah Avner Vengosh Rachel L. Maguire Arnab Maity Carmen Samuel-Hodge Susan K. Murphy Michelle A. Mendez Cathrine Hoyo |
| author_facet | Yiwen Luo Lauren E. McCullough Jung-Ying Tzeng Thomas Darrah Avner Vengosh Rachel L. Maguire Arnab Maity Carmen Samuel-Hodge Susan K. Murphy Michelle A. Mendez Cathrine Hoyo |
| author_sort | Yiwen Luo |
| collection | DOAJ |
| description | Abstract Background Cadmium (Cd), lead (Pb) and arsenic (As) are common environmental contaminants that have been associated with lower birthweight. Although some essential metals may mitigate exposure, data are inconsistent. This study sought to evaluate the relationship between toxic metals, nutrient combinations and birthweight among 275 mother-child pairs. Methods Non-essential metals, Cd, Pb, As, and essential metals, iron (Fe), zinc (Zn), selenium (Se), copper (Cu), calcium (Ca), magnesium (Mg), and manganese (Mn) were measured in maternal whole blood obtained during the first trimester using inductively coupled plasma mass spectrometry. Folate concentrations were measured by microbial assay. Birthweight was obtained from medical records. We used quantile regression to evaluate the association between toxic metals and nutrients due to their underlying wedge-shaped relationship. Ordinary linear regression was used to evaluate associations between birth weight and toxic metals. Results After multivariate adjustment, the negative association between Pb or Cd and a combination of Fe, Se, Ca and folate was robust, persistent and dose-dependent (p < 0.05). However, a combination of Zn, Cu, Mn and Mg was positively associated with Pb and Cd levels. While prenatal blood Cd and Pb were also associated with lower birthweight. Fe, Se, Ca and folate did not modify these associations. Conclusion Small sample size and cross-sectional design notwithstanding, the robust and persistent negative associations between some, but not all, nutrient combinations with these ubiquitous environmental contaminants suggest that only some recommended nutrient combinations may mitigate toxic metal exposure in chronically exposed populations. Larger longitudinal studies are required to confirm these findings. |
| first_indexed | 2024-12-11T00:33:07Z |
| format | Article |
| id | doaj.art-3cd95f49ed1e40788ecd169601069487 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-11T00:33:07Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-3cd95f49ed1e40788ecd1696010694872022-12-22T01:27:15ZengBMCBMC Public Health1471-24582017-04-0117111110.1186/s12889-017-4225-8Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweightYiwen Luo0Lauren E. McCullough1Jung-Ying Tzeng2Thomas Darrah3Avner Vengosh4Rachel L. Maguire5Arnab Maity6Carmen Samuel-Hodge7Susan K. Murphy8Michelle A. Mendez9Cathrine Hoyo10Bioinformatics Research Center, North Carolina State UniversityDepartment of Epidemiology, Emory UniversityBioinformatics Research Center, North Carolina State UniversitySchool of Earth Sciences, The Ohio State UniversityNicholas School of the Environment, Duke UniversityDepartment of Biological Sciences, North Carolina State UniversityDepartment of Statistics, North Carolina State UniversityDepartment of Nutrition, UNCDepartment of OBGYN, Duke UniversityDepartment of Nutrition, UNCDepartment of Biological Sciences, North Carolina State UniversityAbstract Background Cadmium (Cd), lead (Pb) and arsenic (As) are common environmental contaminants that have been associated with lower birthweight. Although some essential metals may mitigate exposure, data are inconsistent. This study sought to evaluate the relationship between toxic metals, nutrient combinations and birthweight among 275 mother-child pairs. Methods Non-essential metals, Cd, Pb, As, and essential metals, iron (Fe), zinc (Zn), selenium (Se), copper (Cu), calcium (Ca), magnesium (Mg), and manganese (Mn) were measured in maternal whole blood obtained during the first trimester using inductively coupled plasma mass spectrometry. Folate concentrations were measured by microbial assay. Birthweight was obtained from medical records. We used quantile regression to evaluate the association between toxic metals and nutrients due to their underlying wedge-shaped relationship. Ordinary linear regression was used to evaluate associations between birth weight and toxic metals. Results After multivariate adjustment, the negative association between Pb or Cd and a combination of Fe, Se, Ca and folate was robust, persistent and dose-dependent (p < 0.05). However, a combination of Zn, Cu, Mn and Mg was positively associated with Pb and Cd levels. While prenatal blood Cd and Pb were also associated with lower birthweight. Fe, Se, Ca and folate did not modify these associations. Conclusion Small sample size and cross-sectional design notwithstanding, the robust and persistent negative associations between some, but not all, nutrient combinations with these ubiquitous environmental contaminants suggest that only some recommended nutrient combinations may mitigate toxic metal exposure in chronically exposed populations. Larger longitudinal studies are required to confirm these findings.http://link.springer.com/article/10.1186/s12889-017-4225-8Toxic metalsDietary nutrientsBirthweightEpidemiology |
| spellingShingle | Yiwen Luo Lauren E. McCullough Jung-Ying Tzeng Thomas Darrah Avner Vengosh Rachel L. Maguire Arnab Maity Carmen Samuel-Hodge Susan K. Murphy Michelle A. Mendez Cathrine Hoyo Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight BMC Public Health Toxic metals Dietary nutrients Birthweight Epidemiology |
| title | Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight |
| title_full | Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight |
| title_fullStr | Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight |
| title_full_unstemmed | Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight |
| title_short | Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight |
| title_sort | maternal blood cadmium lead and arsenic levels nutrient combinations and offspring birthweight |
| topic | Toxic metals Dietary nutrients Birthweight Epidemiology |
| url | http://link.springer.com/article/10.1186/s12889-017-4225-8 |
| work_keys_str_mv | AT yiwenluo maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT laurenemccullough maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT jungyingtzeng maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT thomasdarrah maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT avnervengosh maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT rachellmaguire maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT arnabmaity maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT carmensamuelhodge maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT susankmurphy maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT michelleamendez maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight AT cathrinehoyo maternalbloodcadmiumleadandarseniclevelsnutrientcombinationsandoffspringbirthweight |