Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study
Introduction: There is a paucity of information regarding chronic urticaria patients’ care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticaria patients refractory to H1-antihistamines included in the AWARE stud...
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
2019-02-01
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| Series: | Acta Médica Portuguesa |
| Subjects: | |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9496 |
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| author | Ana Célia Costa Isabel Rosmaninho Arminda Guilherme José Ferreira Joana Antunes Ana Pina Sara Prates João Gaspar Marques Filomena Azevedo Ana Paula Cunha Celeste Brito António Massa João Teles de Sousa Glória Cunha Velho Inês Raposo Gabriela Marques Pinto Virgínia Sousa Ana Rodrigues Martins |
| author_facet | Ana Célia Costa Isabel Rosmaninho Arminda Guilherme José Ferreira Joana Antunes Ana Pina Sara Prates João Gaspar Marques Filomena Azevedo Ana Paula Cunha Celeste Brito António Massa João Teles de Sousa Glória Cunha Velho Inês Raposo Gabriela Marques Pinto Virgínia Sousa Ana Rodrigues Martins |
| author_sort | Ana Célia Costa |
| collection | DOAJ |
| description |
Introduction: There is a paucity of information regarding chronic urticaria patients’ care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticaria patients refractory to H1-antihistamines included in the AWARE study.
Material and Methods: This is a non-interventional cohort study. Adult patients with a diagnosis of chronic urticaria with symptoms for at least two months, refractory to H1-antihistamines, consulting one of the 10 participating urticaria centers throughout Portugal have been included in the study. Baseline sociodemographic data, medical history, clinical parameters, medication, weekly urticaria activity score, and dermatology quality of life index have been collected.
Results: Seventy six patients were included, of which 76.3% were women. The majority of patients had a diagnosis of chronic spontaneous urticaria (88.2%) and 39.5% had angioedema. Around 91.0% of patients were medicated with non-sedative H1-antihistamines and 35.4% with a third line therapy. Median dermatology quality of life index was 5.0 and median weekly urticaria activity score was 13.0.
Discussion: The baseline results suggest that patients with chronic urticaria refractory to H1-antihistamines are being under-treated in the real-world setting.
Conclusion: The AWARE study demonstrates the real impact of chronic urticaria on Portuguese patients refractory to H1-antihistamines treatment, and 30% report a very large or extremely large deleterious effect on their quality of life. The follow-up of these patients will allow evaluating strategies aimed at optimizing disease control.
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| first_indexed | 2024-04-11T10:19:17Z |
| format | Article |
| id | doaj.art-3cdb02d2cf674e3a9e2ee22f7541aeb5 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-11T10:19:17Z |
| publishDate | 2019-02-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-3cdb02d2cf674e3a9e2ee22f7541aeb52022-12-22T04:29:49ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582019-02-0132210.20344/amp.94964812Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE StudyAna Célia Costa0Isabel Rosmaninho1Arminda Guilherme2José Ferreira3Joana Antunes4Ana Pina5Sara Prates6João Gaspar Marques7Filomena Azevedo8Ana Paula Cunha9Celeste Brito10António Massa11João Teles de Sousa12Glória Cunha Velho13Inês Raposo14Gabriela Marques Pinto15Virgínia Sousa16Ana Rodrigues Martins17Serviço de Imunoalergologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa.Serviço de Imunoalergologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia.Serviço de Imunoalergologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia.Serviço de Imunoalergologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia.Serviço de Dermatologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa.Serviço de Dermatologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa.Serviço de Imunoalergologia. Hospital Dona Estefânia. Centro Hospitalar Lisboa Central. Lisboa.Serviço de Imunoalergologia. Hospital Dona Estefânia. Centro Hospitalar Lisboa Central. Lisboa.Serviço de Dermatologia. Centro Hospitalar de São João. Porto.Serviço de Dermatologia. Centro Hospitalar de São João. Porto.Serviço de Dermatologia. Hospital de Braga. Braga.Serviço de Dermatologia. Centro Hospitalar de Vila Nova de Gaia. Vila Nova de Gaia.Serviço de Dermatologia. Hospital Egas Moniz. Centro Hospitalar Lisboa Ocidental. Lisboa.Serviço de Dermatologia. Centro Hospitalar do Porto. Porto.Serviço de Dermatologia. Centro Hospitalar do Porto. Porto.Serviço de Dermatologia. Hospital dos Capuchos. Centro Hospitalar Lisboa Central. Lisboa.Serviço de Dermatologia. Hospital dos Capuchos. Centro Hospitalar Lisboa Central. Lisboa.Novartis Farma – Produtos Farmacêuticos, S.A. Porto Salvo. Introduction: There is a paucity of information regarding chronic urticaria patients’ care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticaria patients refractory to H1-antihistamines included in the AWARE study. Material and Methods: This is a non-interventional cohort study. Adult patients with a diagnosis of chronic urticaria with symptoms for at least two months, refractory to H1-antihistamines, consulting one of the 10 participating urticaria centers throughout Portugal have been included in the study. Baseline sociodemographic data, medical history, clinical parameters, medication, weekly urticaria activity score, and dermatology quality of life index have been collected. Results: Seventy six patients were included, of which 76.3% were women. The majority of patients had a diagnosis of chronic spontaneous urticaria (88.2%) and 39.5% had angioedema. Around 91.0% of patients were medicated with non-sedative H1-antihistamines and 35.4% with a third line therapy. Median dermatology quality of life index was 5.0 and median weekly urticaria activity score was 13.0. Discussion: The baseline results suggest that patients with chronic urticaria refractory to H1-antihistamines are being under-treated in the real-world setting. Conclusion: The AWARE study demonstrates the real impact of chronic urticaria on Portuguese patients refractory to H1-antihistamines treatment, and 30% report a very large or extremely large deleterious effect on their quality of life. The follow-up of these patients will allow evaluating strategies aimed at optimizing disease control. https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9496Chronic DiseaseCost of IllnessHealth ResourcesPortugalQuality of LifeUrticaria |
| spellingShingle | Ana Célia Costa Isabel Rosmaninho Arminda Guilherme José Ferreira Joana Antunes Ana Pina Sara Prates João Gaspar Marques Filomena Azevedo Ana Paula Cunha Celeste Brito António Massa João Teles de Sousa Glória Cunha Velho Inês Raposo Gabriela Marques Pinto Virgínia Sousa Ana Rodrigues Martins Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study Acta Médica Portuguesa Chronic Disease Cost of Illness Health Resources Portugal Quality of Life Urticaria |
| title | Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study |
| title_full | Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study |
| title_fullStr | Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study |
| title_full_unstemmed | Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study |
| title_short | Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study |
| title_sort | chronic urticaria in the real life clinical practice setting in portugal baseline results from the non interventional multicentre aware study |
| topic | Chronic Disease Cost of Illness Health Resources Portugal Quality of Life Urticaria |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9496 |
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