Potential of <i>Kalanchoe pinnata</i> as a Cancer Treatment Adjuvant and an Epigenetic Regulator
Cancer is a global public health problem that is related to different environmental and lifestyle factors. Although the combination of screening, prevention, and treatment of cancer has resulted in increased patient survival, conventional treatments sometimes have therapeutic limitations such as res...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/19/6425 |
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| author | Marta Elena Hernández-Caballero José Alfredo Sierra-Ramírez Ricardo Villalobos-Valencia Emmanuel Seseña-Méndez |
| author_facet | Marta Elena Hernández-Caballero José Alfredo Sierra-Ramírez Ricardo Villalobos-Valencia Emmanuel Seseña-Méndez |
| author_sort | Marta Elena Hernández-Caballero |
| collection | DOAJ |
| description | Cancer is a global public health problem that is related to different environmental and lifestyle factors. Although the combination of screening, prevention, and treatment of cancer has resulted in increased patient survival, conventional treatments sometimes have therapeutic limitations such as resistance to drugs or severe side effects. Oriental culture includes herbal medicine as a complementary therapy in combination with chemotherapy or radiotherapy. This study aimed to identify the bioactive ingredients in <i>Kalanchoe pinnata</i>, a succulent herb with ethnomedical applications for several diseases, including cancer, and reveal its anticancer mechanisms through a molecular approach. The herb contains gallic acid, caffeic acid, coumaric acid, quercetin, quercitrin, isorhamnetin, kaempferol, bersaldegenin, bryophyllin a, bryophyllin c, bryophynol, bryophyllol and bryophollone, stigmasterol, campesterol, and other elements. Its phytochemicals participate in the regulation of proliferation, apoptosis, cell migration, angiogenesis, metastasis, oxidative stress, and autophagy. They have the potential to act as epigenetic drugs by reverting the acquired epigenetic changes associated with tumor resistance to therapy—such as the promoter methylation of suppressor genes, inhibition of DNMT1 and DNMT3b activity, and HDAC regulation—through methylation, thereby regulating the expression of genes involved in the PI3K/Akt/mTOR, Nrf2/Keap1, MEK/ERK, and Wnt/β-catenin pathways. All of the data support the use of <i>K. pinnata</i> as an adjuvant in cancer treatment. |
| first_indexed | 2024-03-09T21:24:29Z |
| format | Article |
| id | doaj.art-3cdb35f0f8af47c6b7c2cdafe79de88a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:24:29Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3cdb35f0f8af47c6b7c2cdafe79de88a2023-11-23T21:11:12ZengMDPI AGMolecules1420-30492022-09-012719642510.3390/molecules27196425Potential of <i>Kalanchoe pinnata</i> as a Cancer Treatment Adjuvant and an Epigenetic RegulatorMarta Elena Hernández-Caballero0José Alfredo Sierra-Ramírez1Ricardo Villalobos-Valencia2Emmanuel Seseña-Méndez3Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Biomedicina, 13 sur 2702 Col. Volcanes, Puebla C.P. 72410, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón Esq. Plan de San Luis S/N, Miguel Hidalgo, Casco de Santo Tomas, Mexico City 11340, MexicoUMAE Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Cd México C.P. 06725, MexicoFacultad de Medicina, Benemérita Universidad Autónoma de Puebla, Biomedicina, 13 sur 2702 Col. Volcanes, Puebla C.P. 72410, MexicoCancer is a global public health problem that is related to different environmental and lifestyle factors. Although the combination of screening, prevention, and treatment of cancer has resulted in increased patient survival, conventional treatments sometimes have therapeutic limitations such as resistance to drugs or severe side effects. Oriental culture includes herbal medicine as a complementary therapy in combination with chemotherapy or radiotherapy. This study aimed to identify the bioactive ingredients in <i>Kalanchoe pinnata</i>, a succulent herb with ethnomedical applications for several diseases, including cancer, and reveal its anticancer mechanisms through a molecular approach. The herb contains gallic acid, caffeic acid, coumaric acid, quercetin, quercitrin, isorhamnetin, kaempferol, bersaldegenin, bryophyllin a, bryophyllin c, bryophynol, bryophyllol and bryophollone, stigmasterol, campesterol, and other elements. Its phytochemicals participate in the regulation of proliferation, apoptosis, cell migration, angiogenesis, metastasis, oxidative stress, and autophagy. They have the potential to act as epigenetic drugs by reverting the acquired epigenetic changes associated with tumor resistance to therapy—such as the promoter methylation of suppressor genes, inhibition of DNMT1 and DNMT3b activity, and HDAC regulation—through methylation, thereby regulating the expression of genes involved in the PI3K/Akt/mTOR, Nrf2/Keap1, MEK/ERK, and Wnt/β-catenin pathways. All of the data support the use of <i>K. pinnata</i> as an adjuvant in cancer treatment.https://www.mdpi.com/1420-3049/27/19/6425<i>Kalanchoe pinnata</i>phytochemicalsantitumor activityadjuvant agent |
| spellingShingle | Marta Elena Hernández-Caballero José Alfredo Sierra-Ramírez Ricardo Villalobos-Valencia Emmanuel Seseña-Méndez Potential of <i>Kalanchoe pinnata</i> as a Cancer Treatment Adjuvant and an Epigenetic Regulator Molecules <i>Kalanchoe pinnata</i> phytochemicals antitumor activity adjuvant agent |
| title | Potential of <i>Kalanchoe pinnata</i> as a Cancer Treatment Adjuvant and an Epigenetic Regulator |
| title_full | Potential of <i>Kalanchoe pinnata</i> as a Cancer Treatment Adjuvant and an Epigenetic Regulator |
| title_fullStr | Potential of <i>Kalanchoe pinnata</i> as a Cancer Treatment Adjuvant and an Epigenetic Regulator |
| title_full_unstemmed | Potential of <i>Kalanchoe pinnata</i> as a Cancer Treatment Adjuvant and an Epigenetic Regulator |
| title_short | Potential of <i>Kalanchoe pinnata</i> as a Cancer Treatment Adjuvant and an Epigenetic Regulator |
| title_sort | potential of i kalanchoe pinnata i as a cancer treatment adjuvant and an epigenetic regulator |
| topic | <i>Kalanchoe pinnata</i> phytochemicals antitumor activity adjuvant agent |
| url | https://www.mdpi.com/1420-3049/27/19/6425 |
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