Curcumin, an Inhibitor of p300-HAT Activity, Suppresses the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats

Curcumin, an Inhibitor of p300-HAT Activity, Suppresses the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats

We found that curcumin, a p300 histone acetyltransferase (HAT) inhibitor, prevents cardiac hypertrophy and systolic dysfunction at the stage of chronic heart failure in Dahl salt-sensitive rats (DS). It is unclear whether curcumin suppresses the development of hypertension-induced left ventricular h...

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Bibliographic Details
Main Authors: Yoichi Sunagawa, Masafumi Funamoto, Kana Shimizu, Satoshi Shimizu, Nurmila Sari, Yasufumi Katanasaka, Yusuke Miyazaki, Hideaki Kakeya, Koji Hasegawa, Tatsuya Morimoto
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Nutrients
Subjects:
p300
curcumin
hypertension
hypertrophy
LVH
Online Access:https://www.mdpi.com/2072-6643/13/8/2608

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