Preparation and Characterisation of Zinc Diethyldithiocarbamate–Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment

Preparation and Characterisation of Zinc Diethyldithiocarbamate–Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment

Zinc diethyldithiocarbamate (Zn (DDC)<sub>2</sub>), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application was limited by its low aqueous solubility and rapid metabolism. In this study, the solubility enhancement of Zn (...

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Bibliographic Details
Main Authors: Ayşe Kaya, Basel Arafat, Havovi Chichger, Ibrahim Tolaymat, Barbara Pierscionek, Mouhamad Khoder, Mohammad Najlah
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceutics
Subjects:
zinc diethyldithiocarbamate
beta-cyclodextrins
solubility
lung cancer
Online Access:https://www.mdpi.com/1999-4923/16/1/65

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