Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice
Satoshi Sakakibara, Noritaka Imamachi, Manabu Sakakihara, Yukiko Katsube, Mai Hattori, Yoji SaitoDepartment of Anesthesiology, Shimane University Faculty of Medicine, Shimane, JapanCorrespondence: Noritaka ImamachiDepartment of Anesthesiology, Shimane University Faculty of Medicine, 89-1 Enyacho Izu...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-08-01
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| Series: | Journal of Pain Research |
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| Online Access: | https://www.dovepress.com/effects-of-an-intrathecal-trpv1-antagonist-sb366791-on-morphine-induce-peer-reviewed-article-JPR |
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| author | Sakakibara S Imamachi N Sakakihara M Katsube Y Hattori M Saito Y |
| author_facet | Sakakibara S Imamachi N Sakakihara M Katsube Y Hattori M Saito Y |
| author_sort | Sakakibara S |
| collection | DOAJ |
| description | Satoshi Sakakibara, Noritaka Imamachi, Manabu Sakakihara, Yukiko Katsube, Mai Hattori, Yoji SaitoDepartment of Anesthesiology, Shimane University Faculty of Medicine, Shimane, JapanCorrespondence: Noritaka ImamachiDepartment of Anesthesiology, Shimane University Faculty of Medicine, 89-1 Enyacho Izumo, Shimane693-8501, JapanTel +81 85 320 2295Fax +81 85 320 2292Email imamachi@med.shimane-u.ac.jpPurpose: Transient receptor potential vanilloid 1 (TRPV1) not only is activated by multiple stimuli but also is involved with histamine-induced itch. The effects of TRPV1 on morphine-induced itch are unknown. We examined the effects of intrathecal administration of TRPV1 antagonist on morphine-induced itch, body temperature, and antinociception for mice.Methods: Each C57/BL6j mouse was intrathecally administered with one of the following solutions: morphine, SB366791 (as the TRPV1 antagonist), morphine + SB366791, saline, or vehicle. For each mouse, each instance of observed scratching behavior was counted, the body temperature was measured, and the nociceptive threshold was determined using the tail-immersion test.Results: SB366791 dose-dependently reduced the scratching behavior induced by the administration of morphine. SB366791 and the morphine + SB366791 groups did not manifest an increase in body temperature. Antinociceptive effects were observed to occur dose-dependently for morphine but not for SB366791. Compared with morphine alone, the administration of morphine + SB366791 did not reduce significant antinociceptive effects.Conclusion: We propose that an intrathecal TRPV1 antagonist, SB366791, reduced morphine-induced itch without causing hyperthermia and did not suppress morphine-induced antinociception for mice.Keywords: pruritus, opioid, TRPV1, nociception, hyperthermia |
| first_indexed | 2024-04-12T21:44:13Z |
| format | Article |
| id | doaj.art-3ce0d2fa857b41f3b5cf2a3c82566d2a |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-04-12T21:44:13Z |
| publishDate | 2019-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-3ce0d2fa857b41f3b5cf2a3c82566d2a2022-12-22T03:15:41ZengDove Medical PressJournal of Pain Research1178-70902019-08-01Volume 122629263648185Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in miceSakakibara SImamachi NSakakihara MKatsube YHattori MSaito YSatoshi Sakakibara, Noritaka Imamachi, Manabu Sakakihara, Yukiko Katsube, Mai Hattori, Yoji SaitoDepartment of Anesthesiology, Shimane University Faculty of Medicine, Shimane, JapanCorrespondence: Noritaka ImamachiDepartment of Anesthesiology, Shimane University Faculty of Medicine, 89-1 Enyacho Izumo, Shimane693-8501, JapanTel +81 85 320 2295Fax +81 85 320 2292Email imamachi@med.shimane-u.ac.jpPurpose: Transient receptor potential vanilloid 1 (TRPV1) not only is activated by multiple stimuli but also is involved with histamine-induced itch. The effects of TRPV1 on morphine-induced itch are unknown. We examined the effects of intrathecal administration of TRPV1 antagonist on morphine-induced itch, body temperature, and antinociception for mice.Methods: Each C57/BL6j mouse was intrathecally administered with one of the following solutions: morphine, SB366791 (as the TRPV1 antagonist), morphine + SB366791, saline, or vehicle. For each mouse, each instance of observed scratching behavior was counted, the body temperature was measured, and the nociceptive threshold was determined using the tail-immersion test.Results: SB366791 dose-dependently reduced the scratching behavior induced by the administration of morphine. SB366791 and the morphine + SB366791 groups did not manifest an increase in body temperature. Antinociceptive effects were observed to occur dose-dependently for morphine but not for SB366791. Compared with morphine alone, the administration of morphine + SB366791 did not reduce significant antinociceptive effects.Conclusion: We propose that an intrathecal TRPV1 antagonist, SB366791, reduced morphine-induced itch without causing hyperthermia and did not suppress morphine-induced antinociception for mice.Keywords: pruritus, opioid, TRPV1, nociception, hyperthermiahttps://www.dovepress.com/effects-of-an-intrathecal-trpv1-antagonist-sb366791-on-morphine-induce-peer-reviewed-article-JPRpruritusopioidTRPV1nociceptionhyperthermia |
| spellingShingle | Sakakibara S Imamachi N Sakakihara M Katsube Y Hattori M Saito Y Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice Journal of Pain Research pruritus opioid TRPV1 nociception hyperthermia |
| title | Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice |
| title_full | Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice |
| title_fullStr | Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice |
| title_full_unstemmed | Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice |
| title_short | Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice |
| title_sort | effects of an intrathecal trpv1 antagonist sb366791 on morphine induced itch body temperature and antinociception in mice |
| topic | pruritus opioid TRPV1 nociception hyperthermia |
| url | https://www.dovepress.com/effects-of-an-intrathecal-trpv1-antagonist-sb366791-on-morphine-induce-peer-reviewed-article-JPR |
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