Isolation of biomedically important bioactive compounds from Debregeasia salicifolia with extraordinary antioxidant potential hepato-protectivity
Debregeasia salicifolia is a widely used medicinal plant that has been used traditionally to cope up different ailments but received little research. So, we have investigated the hepatoprotective and antioxidant properties and also performed chemical profiling by using GC–MS, HPLC and FT-IR techniqu...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364722006401 |
| _version_ | 1797952839289405440 |
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| author | Salina Saddick Dawood Ahmed Hina Gul |
| author_facet | Salina Saddick Dawood Ahmed Hina Gul |
| author_sort | Salina Saddick |
| collection | DOAJ |
| description | Debregeasia salicifolia is a widely used medicinal plant that has been used traditionally to cope up different ailments but received little research. So, we have investigated the hepatoprotective and antioxidant properties and also performed chemical profiling by using GC–MS, HPLC and FT-IR techniques. Their analysis revealed the presence of flavonoids, phenols and fatty acids. Albino mice were used for conducting hepatoprotective assay using CCl4 with three methanol and chloroform extract dosages of (100, 200, and 300 mg/kg b.w.) along with silymarin serving as a positive control. Blood was tested for liver markers to see if they had any hepatoprotective effects. Furthermore, to check healing ability in mice, tests were done by analyzing liver biochemical markers, antioxidant enzymes and direct bilirubins. The high dose of DSM (300 mg/kg b.w) had the most potent hepatoprotective effects on CCl4-induced abnormalities. The in vitro antioxidant, as well as the high quantities of flavonoids in the extracts, coincided well with the in vivo hepatoprotective benefits. |
| first_indexed | 2024-04-10T22:52:21Z |
| format | Article |
| id | doaj.art-3ce20ab9304f4717a89ba425488bf6ab |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-04-10T22:52:21Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-3ce20ab9304f4717a89ba425488bf6ab2023-01-15T04:21:13ZengElsevierJournal of King Saud University: Science1018-36472023-02-01352102459Isolation of biomedically important bioactive compounds from Debregeasia salicifolia with extraordinary antioxidant potential hepato-protectivitySalina Saddick0Dawood Ahmed1Hina Gul2Department of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia; Corresponding authors.Department of Medical Lab Technology, University of Harper, KPK, PakistanUniversity Institute of Biochemistry and Biotechnology (UIBB), PMAS Arid Agriculture University, Rawalpindi, Pakistan; Corresponding authors.Debregeasia salicifolia is a widely used medicinal plant that has been used traditionally to cope up different ailments but received little research. So, we have investigated the hepatoprotective and antioxidant properties and also performed chemical profiling by using GC–MS, HPLC and FT-IR techniques. Their analysis revealed the presence of flavonoids, phenols and fatty acids. Albino mice were used for conducting hepatoprotective assay using CCl4 with three methanol and chloroform extract dosages of (100, 200, and 300 mg/kg b.w.) along with silymarin serving as a positive control. Blood was tested for liver markers to see if they had any hepatoprotective effects. Furthermore, to check healing ability in mice, tests were done by analyzing liver biochemical markers, antioxidant enzymes and direct bilirubins. The high dose of DSM (300 mg/kg b.w) had the most potent hepatoprotective effects on CCl4-induced abnormalities. The in vitro antioxidant, as well as the high quantities of flavonoids in the extracts, coincided well with the in vivo hepatoprotective benefits.http://www.sciencedirect.com/science/article/pii/S1018364722006401Debregeasia salicifoliaPhytochemical screeningAntioxidant propertyHepatoprotective activity |
| spellingShingle | Salina Saddick Dawood Ahmed Hina Gul Isolation of biomedically important bioactive compounds from Debregeasia salicifolia with extraordinary antioxidant potential hepato-protectivity Journal of King Saud University: Science Debregeasia salicifolia Phytochemical screening Antioxidant property Hepatoprotective activity |
| title | Isolation of biomedically important bioactive compounds from Debregeasia salicifolia with extraordinary antioxidant potential hepato-protectivity |
| title_full | Isolation of biomedically important bioactive compounds from Debregeasia salicifolia with extraordinary antioxidant potential hepato-protectivity |
| title_fullStr | Isolation of biomedically important bioactive compounds from Debregeasia salicifolia with extraordinary antioxidant potential hepato-protectivity |
| title_full_unstemmed | Isolation of biomedically important bioactive compounds from Debregeasia salicifolia with extraordinary antioxidant potential hepato-protectivity |
| title_short | Isolation of biomedically important bioactive compounds from Debregeasia salicifolia with extraordinary antioxidant potential hepato-protectivity |
| title_sort | isolation of biomedically important bioactive compounds from debregeasia salicifolia with extraordinary antioxidant potential hepato protectivity |
| topic | Debregeasia salicifolia Phytochemical screening Antioxidant property Hepatoprotective activity |
| url | http://www.sciencedirect.com/science/article/pii/S1018364722006401 |
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