DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers

DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers

Abstract Background Little is known about the role of global DNA methylation in recurrence and chemoresistance of high grade serous ovarian cancer (HGSOC). Methods We performed whole genome bisulfite sequencing and transcriptome sequencing in 62 primary and recurrent tumors from 28 patients with sta...

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Bibliographic Details
Main Authors: Nicole Gull, Michelle R. Jones, Pei-Chen Peng, Simon G. Coetzee, Tiago C. Silva, Jasmine T. Plummer, Alberto Luiz P. Reyes, Brian D. Davis, Stephanie S. Chen, Kate Lawrenson, Jenny Lester, Christine Walsh, Bobbie J. Rimel, Andrew J. Li, Ilana Cass, Yonatan Berg, John-Paul B. Govindavari, Joanna K. L. Rutgers, Benjamin P. Berman, Beth Y. Karlan, Simon A. Gayther
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
High grade serous ovarian cancer
Methylation
Chemoresistance
Epigenetics
Whole genome bisulfite sequencing
Computational methods
Online Access:https://doi.org/10.1186/s13046-022-02440-z

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