Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment
Background/aims: The genome-wide association study has shown that MHC class I chain-related A (MICA) genetic variants were associated with hepatitis C virus (HCC) related hepatocellular carcinoma. The impact of the genetic variants and its serum levels on post-treatment cohort is elusive. Methods: M...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396416305497 |
| _version_ | 1818619268689821696 |
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| author | Chung-Feng Huang Cing-Yi Huang Ming-Lun Yeh Shu-Chi Wang Kuan-Yu Chen Yu-Min Ko Ching-Chih Lin Yi-Shan Tsai Pei-Chien Tsai Zu-Yau Lin Shinn-Cherng Chen Chia-Yen Dai Jee-Fu Huang Wan-Long Chuang Ming-Lung Yu |
| author_facet | Chung-Feng Huang Cing-Yi Huang Ming-Lun Yeh Shu-Chi Wang Kuan-Yu Chen Yu-Min Ko Ching-Chih Lin Yi-Shan Tsai Pei-Chien Tsai Zu-Yau Lin Shinn-Cherng Chen Chia-Yen Dai Jee-Fu Huang Wan-Long Chuang Ming-Lung Yu |
| author_sort | Chung-Feng Huang |
| collection | DOAJ |
| description | Background/aims: The genome-wide association study has shown that MHC class I chain-related A (MICA) genetic variants were associated with hepatitis C virus (HCC) related hepatocellular carcinoma. The impact of the genetic variants and its serum levels on post-treatment cohort is elusive.
Methods: MICA rs2596542 genotype and serum MICA (sMICA) levels were evaluated in 705 patients receiving antiviral therapy.
Results: Fifty-eight (8·2%) patients developed HCC, with a median follow-up period of 48·2 months (range: 6–129 months). The MICA A allele was associated with a significantly increased risk of HCC development in cirrhotic non-SVR patients but not in patients of non-cirrhotic and/or with SVR. For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26.38·61, P = 0·002) and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development. The risk A allele or GG genotype with sMICA > 175 ng/mL provided the best accuracy (79%) and a negative predictive value of 100% in predicting HCC.
Conclusions: Cirrhotic patients who carry MICA risk alleles and those without risk alleles but with high sMICA levels possessed the highest risk of HCC development once they failed antiviral therapy. |
| first_indexed | 2024-12-16T17:34:47Z |
| format | Article |
| id | doaj.art-3ce3c35d2637413987947d14e3fe1ddd |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-16T17:34:47Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-3ce3c35d2637413987947d14e3fe1ddd2022-12-21T22:22:50ZengElsevierEBioMedicine2352-39642017-02-0115C818910.1016/j.ebiom.2016.11.031Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral TreatmentChung-Feng Huang0Cing-Yi Huang1Ming-Lun Yeh2Shu-Chi Wang3Kuan-Yu Chen4Yu-Min Ko5Ching-Chih Lin6Yi-Shan Tsai7Pei-Chien Tsai8Zu-Yau Lin9Shinn-Cherng Chen10Chia-Yen Dai11Jee-Fu Huang12Wan-Long Chuang13Ming-Lung Yu14Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanBackground/aims: The genome-wide association study has shown that MHC class I chain-related A (MICA) genetic variants were associated with hepatitis C virus (HCC) related hepatocellular carcinoma. The impact of the genetic variants and its serum levels on post-treatment cohort is elusive. Methods: MICA rs2596542 genotype and serum MICA (sMICA) levels were evaluated in 705 patients receiving antiviral therapy. Results: Fifty-eight (8·2%) patients developed HCC, with a median follow-up period of 48·2 months (range: 6–129 months). The MICA A allele was associated with a significantly increased risk of HCC development in cirrhotic non-SVR patients but not in patients of non-cirrhotic and/or with SVR. For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26.38·61, P = 0·002) and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development. The risk A allele or GG genotype with sMICA > 175 ng/mL provided the best accuracy (79%) and a negative predictive value of 100% in predicting HCC. Conclusions: Cirrhotic patients who carry MICA risk alleles and those without risk alleles but with high sMICA levels possessed the highest risk of HCC development once they failed antiviral therapy.http://www.sciencedirect.com/science/article/pii/S2352396416305497HCCSVRSNPMICAPNPLA3IL-28EGFsMICATreatment |
| spellingShingle | Chung-Feng Huang Cing-Yi Huang Ming-Lun Yeh Shu-Chi Wang Kuan-Yu Chen Yu-Min Ko Ching-Chih Lin Yi-Shan Tsai Pei-Chien Tsai Zu-Yau Lin Shinn-Cherng Chen Chia-Yen Dai Jee-Fu Huang Wan-Long Chuang Ming-Lung Yu Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment EBioMedicine HCC SVR SNP MICA PNPLA3 IL-28 EGF sMICA Treatment |
| title | Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment |
| title_full | Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment |
| title_fullStr | Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment |
| title_full_unstemmed | Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment |
| title_short | Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment |
| title_sort | genetics variants and serum levels of mhc class i chain related a in predicting hepatocellular carcinoma development in chronic hepatitis c patients post antiviral treatment |
| topic | HCC SVR SNP MICA PNPLA3 IL-28 EGF sMICA Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2352396416305497 |
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