The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C
Abstract Background Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergenc...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Trials |
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| Online Access: | https://doi.org/10.1186/s13063-022-07018-w |
| _version_ | 1811175677786849280 |
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| author | Sarah E. Rowan Jason Haukoos Kevin F. Kamis Emily Hopkins Stephanie Gravitz Carolynn Lyle Alia A. Al-Tayyib Edward M. Gardner James W. Galbraith Yu-Hsiang Hsieh Michael S. Lyons Richard E. Rothman Douglas A. E. White Jake R. Morgan Benjamin P. Linas Allison L. Sabel David L. Wyles for The DETECT Hep C Trials Investigators |
| author_facet | Sarah E. Rowan Jason Haukoos Kevin F. Kamis Emily Hopkins Stephanie Gravitz Carolynn Lyle Alia A. Al-Tayyib Edward M. Gardner James W. Galbraith Yu-Hsiang Hsieh Michael S. Lyons Richard E. Rothman Douglas A. E. White Jake R. Morgan Benjamin P. Linas Allison L. Sabel David L. Wyles for The DETECT Hep C Trials Investigators |
| author_sort | Sarah E. Rowan |
| collection | DOAJ |
| description | Abstract Background Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departments (EDs) serve as an important clinical setting for HCV screening, although optimal methods of linkage-to-care for HCV-diagnosed individuals remain unknown. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial. Methods The DETECT Hep C Linkage-to-Care Trial will be a single-center prospective comparative effectiveness randomized two-arm parallel-group superiority trial to test the effectiveness of linkage navigation and clinician referral among ED patients identified with untreated HCV with a primary hypothesis that linkage navigation plus clinician referral is superior to clinician referral alone when using treatment initiation as the primary outcome. Participants will be enrolled in the ED at Denver Health Medical Center (Denver, CO), an urban, safety-net hospital with approximately 75,000 annual adult ED visits. This trial was designed to enroll a maximum of 280 HCV RNA-positive participants with one planned interim analysis based on methods by O’Brien and Fleming. This trial will further inform the evaluation of cost effectiveness, disparities, and social determinants of health in linkage-to-care, treatment, and disease progression. Discussion When complete, the DETECT Hep C Linkage-to-Care Trial will significantly inform how best to perform linkage-to-care among ED patients identified with HCV. Trial registration ClinicalTrials.gov ID: NCT04026867 Original date: July 1, 2019 URL: https://clinicaltrials.gov/ct2/show/NCT04026867 |
| first_indexed | 2024-04-10T19:40:43Z |
| format | Article |
| id | doaj.art-3ce5f8e4033e427b86c9a6144af9bf60 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-04-10T19:40:43Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-3ce5f8e4033e427b86c9a6144af9bf602023-01-29T12:21:15ZengBMCTrials1745-62152023-01-012411910.1186/s13063-022-07018-wThe Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis CSarah E. Rowan0Jason Haukoos1Kevin F. Kamis2Emily Hopkins3Stephanie Gravitz4Carolynn Lyle5Alia A. Al-Tayyib6Edward M. Gardner7James W. Galbraith8Yu-Hsiang Hsieh9Michael S. Lyons10Richard E. Rothman11Douglas A. E. White12Jake R. Morgan13Benjamin P. Linas14Allison L. Sabel15David L. Wyles16for The DETECT Hep C Trials InvestigatorsDivision of Infectious Diseases, Denver Health Medical Center and University of Colorado School of MedicineDepartment of Emergency Medicine, Denver Health Medical Center and University of Colorado School of MedicinePublic Health Institute at Denver HealthDepartment of Emergency Medicine, Denver Health Medical Center and University of Colorado School of MedicineDepartment of Emergency Medicine, Denver Health Medical Center and University of Colorado School of MedicineDepartment of Emergency Medicine, Denver Health Medical Center and University of Colorado School of MedicinePublic Health Institute at Denver HealthDivision of Infectious Diseases, Denver Health Medical Center and University of Colorado School of MedicineDepartment of Emergency Medicine, University of Mississippi Medical CenterDepartment of Emergency Medicine, Johns Hopkins UniversityDepartment of Emergency Medicine, The Ohio State University Wexner Medical CenterDepartment of Emergency Medicine, Johns Hopkins UniversityDepartment of Emergency Medicine, Highland Hospital, Alameda Health SystemDepartment of Health Law, Policy, and Management, Boston University School of Public HealthCenter for Health Economics of Treatment Interventions for Substance Use Disorder, HCV, and HIVDepartment of Patient Safety and Quality, Denver HealthDivision of Infectious Diseases, Denver Health Medical Center and University of Colorado School of MedicineAbstract Background Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departments (EDs) serve as an important clinical setting for HCV screening, although optimal methods of linkage-to-care for HCV-diagnosed individuals remain unknown. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial. Methods The DETECT Hep C Linkage-to-Care Trial will be a single-center prospective comparative effectiveness randomized two-arm parallel-group superiority trial to test the effectiveness of linkage navigation and clinician referral among ED patients identified with untreated HCV with a primary hypothesis that linkage navigation plus clinician referral is superior to clinician referral alone when using treatment initiation as the primary outcome. Participants will be enrolled in the ED at Denver Health Medical Center (Denver, CO), an urban, safety-net hospital with approximately 75,000 annual adult ED visits. This trial was designed to enroll a maximum of 280 HCV RNA-positive participants with one planned interim analysis based on methods by O’Brien and Fleming. This trial will further inform the evaluation of cost effectiveness, disparities, and social determinants of health in linkage-to-care, treatment, and disease progression. Discussion When complete, the DETECT Hep C Linkage-to-Care Trial will significantly inform how best to perform linkage-to-care among ED patients identified with HCV. Trial registration ClinicalTrials.gov ID: NCT04026867 Original date: July 1, 2019 URL: https://clinicaltrials.gov/ct2/show/NCT04026867https://doi.org/10.1186/s13063-022-07018-wHepatitis CHCVLinkage-to-careNavigationClinical trialRandomized trial |
| spellingShingle | Sarah E. Rowan Jason Haukoos Kevin F. Kamis Emily Hopkins Stephanie Gravitz Carolynn Lyle Alia A. Al-Tayyib Edward M. Gardner James W. Galbraith Yu-Hsiang Hsieh Michael S. Lyons Richard E. Rothman Douglas A. E. White Jake R. Morgan Benjamin P. Linas Allison L. Sabel David L. Wyles for The DETECT Hep C Trials Investigators The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C Trials Hepatitis C HCV Linkage-to-care Navigation Clinical trial Randomized trial |
| title | The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C |
| title_full | The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C |
| title_fullStr | The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C |
| title_full_unstemmed | The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C |
| title_short | The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C |
| title_sort | determining effective testing in emergency departments and care coordination on treatment outcomes detect for hepatitis c hep c linkage to care trial rationale and design of an emergency department based randomized clinical trial of linkage to care strategies for hepatitis c |
| topic | Hepatitis C HCV Linkage-to-care Navigation Clinical trial Randomized trial |
| url | https://doi.org/10.1186/s13063-022-07018-w |
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