<span style="font-variant: small-caps">d</span>-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability

<span style="font-variant: small-caps">d</span>-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability

α-Conotoxin RgIA is a selective and potent competitive antagonist of rat α9α10 nicotinic acetylcholine receptors (nAChR), but it is much less potent towards human α9α10 nAChR. Furthermore, RgIA is susceptible to proteolytic degradation due to containing f...

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Bibliographic Details
Main Authors:	Jie Ren, Xiaopeng Zhu, Pan Xu, Rui Li, Ying Fu, Shuai Dong, Dongting Zhangsun, Yong Wu, Sulan Luo
Format:	Article
Language:	English
Published:	MDPI AG 2019-02-01
Series:	Marine Drugs
Subjects:	<span style="font-variant: small-caps">d</span>-amino acid scan α-conotoxin RgIA α9α10 nAChR activity stability
Online Access:	https://www.mdpi.com/1660-3397/17/3/142

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