Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue
The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during Dengu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/10/3/104 |
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| author | Eneida S. Oliveira Stella G. Colombarolli Camila S. Nascimento Izabella C. A. Batista Jorge G. G. Ferreira Daniele L. R. Alvarenga Laís O. B. de Sousa Rafael R. Assis Marcele N. Rocha Érica A. R. Alves Carlos E. Calzavara-Silva |
| author_facet | Eneida S. Oliveira Stella G. Colombarolli Camila S. Nascimento Izabella C. A. Batista Jorge G. G. Ferreira Daniele L. R. Alvarenga Laís O. B. de Sousa Rafael R. Assis Marcele N. Rocha Érica A. R. Alves Carlos E. Calzavara-Silva |
| author_sort | Eneida S. Oliveira |
| collection | DOAJ |
| description | The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during Dengue virus infection, plasma levels of thromboxane A2, prostaglandin E2 and leukotriene B4; mRNA levels of thromboxane A2 synthase, prostaglandin E2 synthase, leukotriene A4 hydrolase, cyclooxygenase-2 and 5-lipoxygenase; and the levels of lipid bodies in peripheral blood leukocytes collected from IgM-positive and IgM-negative volunteers with mild dengue, and non-infected volunteers, were evaluated. Dengue virus infection increases the levels of thromboxane A2 in IgM-positive individuals as well as the amount of lipid bodies in monocytes in IgM-negative individuals. We suggest that increased levels of thromboxane A2 in IgM-positive individuals plays a protective role against the development of severe symptoms of dengue, such as vascular leakage. |
| first_indexed | 2024-12-21T23:29:35Z |
| format | Article |
| id | doaj.art-3ce6fa20c8154cb0b4de1302b1c723da |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-21T23:29:35Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-3ce6fa20c8154cb0b4de1302b1c723da2022-12-21T18:46:32ZengMDPI AGViruses1999-49152018-02-0110310410.3390/v10030104v10030104Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of DengueEneida S. Oliveira0Stella G. Colombarolli1Camila S. Nascimento2Izabella C. A. Batista3Jorge G. G. Ferreira4Daniele L. R. Alvarenga5Laís O. B. de Sousa6Rafael R. Assis7Marcele N. Rocha8Érica A. R. Alves9Carlos E. Calzavara-Silva10Imunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, BrazilImunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, BrazilImunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, BrazilImunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, BrazilImunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, BrazilImunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, BrazilSanta Casa de Misericórdia de Santo Antônio do Monte, Santo Antônio do Monte 35560-000, BrazilImunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, BrazilMosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou, Belo Horizonte 30190-002, BrazilImunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, BrazilImunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, BrazilThe inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during Dengue virus infection, plasma levels of thromboxane A2, prostaglandin E2 and leukotriene B4; mRNA levels of thromboxane A2 synthase, prostaglandin E2 synthase, leukotriene A4 hydrolase, cyclooxygenase-2 and 5-lipoxygenase; and the levels of lipid bodies in peripheral blood leukocytes collected from IgM-positive and IgM-negative volunteers with mild dengue, and non-infected volunteers, were evaluated. Dengue virus infection increases the levels of thromboxane A2 in IgM-positive individuals as well as the amount of lipid bodies in monocytes in IgM-negative individuals. We suggest that increased levels of thromboxane A2 in IgM-positive individuals plays a protective role against the development of severe symptoms of dengue, such as vascular leakage.http://www.mdpi.com/1999-4915/10/3/104Dengue viruseicosanoidscyclooxygenase-25-lipoxygenaselipid bodies |
| spellingShingle | Eneida S. Oliveira Stella G. Colombarolli Camila S. Nascimento Izabella C. A. Batista Jorge G. G. Ferreira Daniele L. R. Alvarenga Laís O. B. de Sousa Rafael R. Assis Marcele N. Rocha Érica A. R. Alves Carlos E. Calzavara-Silva Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue Viruses Dengue virus eicosanoids cyclooxygenase-2 5-lipoxygenase lipid bodies |
| title | Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue |
| title_full | Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue |
| title_fullStr | Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue |
| title_full_unstemmed | Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue |
| title_short | Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue |
| title_sort | increased levels of txa2 induced by dengue virus infection in igm positive individuals is related to the mild symptoms of dengue |
| topic | Dengue virus eicosanoids cyclooxygenase-2 5-lipoxygenase lipid bodies |
| url | http://www.mdpi.com/1999-4915/10/3/104 |
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