Uncertainty-Dependent Extinction of Fear Memory in an Amygdala-mPFC Neural Circuit Model.

Uncertainty of fear conditioning is crucial for the acquisition and extinction of fear memory. Fear memory acquired through partial pairings of a conditioned stimulus (CS) and an unconditioned stimulus (US) is more resistant to extinction than that acquired through full pairings; this effect is know...

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Bibliographic Details
Main Authors: Yuzhe Li, Ken Nakae, Shin Ishii, Honda Naoki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1005099