Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults
Background We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin was measured by enzyme-linked immunosorb...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2021-10-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2021-1104.pdf |
| _version_ | 1828902950595985408 |
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| author | Yeliana L. Sánchez Manuela Yepes-Calderón Luis Valbuena Andrés F. Milán María C. Trillos-Almanza Sergio Granados Miguel Peña Mauricio Estrada-Castrillón Juan C. Aristizábal Raúl Narvez-Sanchez Jaime Gallo-Villegas Juan C. Calderón |
| author_facet | Yeliana L. Sánchez Manuela Yepes-Calderón Luis Valbuena Andrés F. Milán María C. Trillos-Almanza Sergio Granados Miguel Peña Mauricio Estrada-Castrillón Juan C. Aristizábal Raúl Narvez-Sanchez Jaime Gallo-Villegas Juan C. Calderón |
| author_sort | Yeliana L. Sánchez |
| collection | DOAJ |
| description | Background We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin was measured by enzyme-linked immunosorbent assay. Insulin resistance (IR) was evaluated by the homeostatic model assessment (HOMA-IR). Body composition was determined by dual-energy X-ray absorptiometry and muscle composition by measuring carnosine in the thigh, a surrogate of fiber types, through proton magnetic resonance spectroscopy. Cardiorespiratory capacity was assessed through direct ergospirometry. Results The control (n=29) and MS (n=61) groups were comparable in age (51.5±6.5 years old vs. 50.7±6.1 years old), sex (72.4% vs. 70.5% women), total lean mass (58.5%±7.4% vs. 57.3%±6.8%), and peak oxygen consumption (VO2peak) (31.0±5.8 mL O2./kg.min vs. 29.2±6.3 mL O2/kg.min). Individuals with MS had higher body mass index (BMI) (30.6±4.0 kg/m2 vs. 27.4±3.6 kg/m2), HOMA-IR (3.5 [95% confidence interval, CI, 2.9 to 4.6] vs. 1.7 [95% CI, 1.1 to 2.0]), and musclin (206.7 pg/mL [95% CI, 122.7 to 387.8] vs. 111.1 pg/mL [95% CI, 63.2 to 218.5]) values than controls (P<0.05). Musclin showed a significant relationship with HOMA-IR (β=0.23; 95% CI, 0.12 to 0.33; P<0.01), but not with VO2peak, in multiple linear regression models adjusted for age, sex, fat mass, lean mass, and physical activity. Musclin was significantly associated with insulin, glycemia, visceral fat, and regional muscle mass, but not with BMI, VCO2peak, maximum heart rate, maximum time of work, or carnosine. Conclusion In humans, musclin positively correlates with insulinemia, IR, and a body composition profile with high visceral adiposity and lean mass, but low body fat percentage. Musclin is not related to BMI or cardiorespiratory capacity. |
| first_indexed | 2024-12-13T16:26:51Z |
| format | Article |
| id | doaj.art-3ce9695bcb0149cd83dc5889b593bbaa |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-13T16:26:51Z |
| publishDate | 2021-10-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-3ce9695bcb0149cd83dc5889b593bbaa2022-12-21T23:38:35ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782021-10-013651055106810.3803/EnM.2021.11042221Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in AdultsYeliana L. Sánchez0Manuela Yepes-Calderón1Luis Valbuena2Andrés F. Milán3María C. Trillos-Almanza4Sergio Granados5Miguel Peña6Mauricio Estrada-Castrillón7Juan C. Aristizábal8Raúl Narvez-Sanchez9Jaime Gallo-Villegas10Juan C. Calderón11 Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Pablo Tobón Uribe Hospital, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, Colombia Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellin, ColombiaBackground We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin was measured by enzyme-linked immunosorbent assay. Insulin resistance (IR) was evaluated by the homeostatic model assessment (HOMA-IR). Body composition was determined by dual-energy X-ray absorptiometry and muscle composition by measuring carnosine in the thigh, a surrogate of fiber types, through proton magnetic resonance spectroscopy. Cardiorespiratory capacity was assessed through direct ergospirometry. Results The control (n=29) and MS (n=61) groups were comparable in age (51.5±6.5 years old vs. 50.7±6.1 years old), sex (72.4% vs. 70.5% women), total lean mass (58.5%±7.4% vs. 57.3%±6.8%), and peak oxygen consumption (VO2peak) (31.0±5.8 mL O2./kg.min vs. 29.2±6.3 mL O2/kg.min). Individuals with MS had higher body mass index (BMI) (30.6±4.0 kg/m2 vs. 27.4±3.6 kg/m2), HOMA-IR (3.5 [95% confidence interval, CI, 2.9 to 4.6] vs. 1.7 [95% CI, 1.1 to 2.0]), and musclin (206.7 pg/mL [95% CI, 122.7 to 387.8] vs. 111.1 pg/mL [95% CI, 63.2 to 218.5]) values than controls (P<0.05). Musclin showed a significant relationship with HOMA-IR (β=0.23; 95% CI, 0.12 to 0.33; P<0.01), but not with VO2peak, in multiple linear regression models adjusted for age, sex, fat mass, lean mass, and physical activity. Musclin was significantly associated with insulin, glycemia, visceral fat, and regional muscle mass, but not with BMI, VCO2peak, maximum heart rate, maximum time of work, or carnosine. Conclusion In humans, musclin positively correlates with insulinemia, IR, and a body composition profile with high visceral adiposity and lean mass, but low body fat percentage. Musclin is not related to BMI or cardiorespiratory capacity.http://www.e-enm.org/upload/pdf/enm-2021-1104.pdfhormonesmusclin proteinhuman (ostn)metabolic syndromeinsulin resistancemuscleskeletalbody composition |
| spellingShingle | Yeliana L. Sánchez Manuela Yepes-Calderón Luis Valbuena Andrés F. Milán María C. Trillos-Almanza Sergio Granados Miguel Peña Mauricio Estrada-Castrillón Juan C. Aristizábal Raúl Narvez-Sanchez Jaime Gallo-Villegas Juan C. Calderón Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults Endocrinology and Metabolism hormones musclin protein human (ostn) metabolic syndrome insulin resistance muscle skeletal body composition |
| title | Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults |
| title_full | Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults |
| title_fullStr | Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults |
| title_full_unstemmed | Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults |
| title_short | Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults |
| title_sort | musclin is related to insulin resistance and body composition but not to body mass index or cardiorespiratory capacity in adults |
| topic | hormones musclin protein human (ostn) metabolic syndrome insulin resistance muscle skeletal body composition |
| url | http://www.e-enm.org/upload/pdf/enm-2021-1104.pdf |
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