Spatial and Temporal Dynamics and Molecular Evolution of <i>Tula orthohantavirus</i> in German Vole Populations
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (<i>Microtus arvalis</i>), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplit...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/6/1132 |
| _version_ | 1797530380326141952 |
|---|---|
| author | Sabrina Schmidt Daniela Reil Kathrin Jeske Stephan Drewes Ulrike M. Rosenfeld Stefan Fischer Nastasja G. Spierling Anton Labutin Gerald Heckel Jens Jacob Rainer G. Ulrich Christian Imholt |
| author_facet | Sabrina Schmidt Daniela Reil Kathrin Jeske Stephan Drewes Ulrike M. Rosenfeld Stefan Fischer Nastasja G. Spierling Anton Labutin Gerald Heckel Jens Jacob Rainer G. Ulrich Christian Imholt |
| author_sort | Sabrina Schmidt |
| collection | DOAJ |
| description | Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (<i>Microtus arvalis</i>), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host–pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics. |
| first_indexed | 2024-03-10T10:28:06Z |
| format | Article |
| id | doaj.art-3ce99ac8a6334e48baf6603b22efd8da |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:28:06Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-3ce99ac8a6334e48baf6603b22efd8da2023-11-21T23:49:46ZengMDPI AGViruses1999-49152021-06-01136113210.3390/v13061132Spatial and Temporal Dynamics and Molecular Evolution of <i>Tula orthohantavirus</i> in German Vole PopulationsSabrina Schmidt0Daniela Reil1Kathrin Jeske2Stephan Drewes3Ulrike M. Rosenfeld4Stefan Fischer5Nastasja G. Spierling6Anton Labutin7Gerald Heckel8Jens Jacob9Rainer G. Ulrich10Christian Imholt11Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, GermanyAnimal Ecology, Institute of Biochemistry and Biology, University of Potsdam, 14469 Potsdam, GermanyInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, GermanyInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, GermanyInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, GermanyInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, GermanyInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, GermanyInstitute of Ecology and Evolution, University of Bern, 3012 Bern, SwitzerlandInstitute of Ecology and Evolution, University of Bern, 3012 Bern, SwitzerlandInstitute for Plant Protection in Horticulture and Forests, Julius Kühn-Institute (JKI), 48161 Münster, GermanyInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, GermanyInstitute for Plant Protection in Horticulture and Forests, Julius Kühn-Institute (JKI), 48161 Münster, GermanyTula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (<i>Microtus arvalis</i>), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host–pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics.https://www.mdpi.com/1999-4915/13/6/1132rodentshantavirusmonitoringpopulation dynamicscommon volefield vole |
| spellingShingle | Sabrina Schmidt Daniela Reil Kathrin Jeske Stephan Drewes Ulrike M. Rosenfeld Stefan Fischer Nastasja G. Spierling Anton Labutin Gerald Heckel Jens Jacob Rainer G. Ulrich Christian Imholt Spatial and Temporal Dynamics and Molecular Evolution of <i>Tula orthohantavirus</i> in German Vole Populations Viruses rodents hantavirus monitoring population dynamics common vole field vole |
| title | Spatial and Temporal Dynamics and Molecular Evolution of <i>Tula orthohantavirus</i> in German Vole Populations |
| title_full | Spatial and Temporal Dynamics and Molecular Evolution of <i>Tula orthohantavirus</i> in German Vole Populations |
| title_fullStr | Spatial and Temporal Dynamics and Molecular Evolution of <i>Tula orthohantavirus</i> in German Vole Populations |
| title_full_unstemmed | Spatial and Temporal Dynamics and Molecular Evolution of <i>Tula orthohantavirus</i> in German Vole Populations |
| title_short | Spatial and Temporal Dynamics and Molecular Evolution of <i>Tula orthohantavirus</i> in German Vole Populations |
| title_sort | spatial and temporal dynamics and molecular evolution of i tula orthohantavirus i in german vole populations |
| topic | rodents hantavirus monitoring population dynamics common vole field vole |
| url | https://www.mdpi.com/1999-4915/13/6/1132 |
| work_keys_str_mv | AT sabrinaschmidt spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT danielareil spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT kathrinjeske spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT stephandrewes spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT ulrikemrosenfeld spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT stefanfischer spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT nastasjagspierling spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT antonlabutin spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT geraldheckel spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT jensjacob spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT rainergulrich spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations AT christianimholt spatialandtemporaldynamicsandmolecularevolutionofitulaorthohantavirusiingermanvolepopulations |