The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (re...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2014-08-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500608&lng=en&tlng=en |
| _version_ | 1827839631065874432 |
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| author | Taís Nóbrega de Sousa Flora Satiko Kano Cristiana Ferreira Alves de Brito Luzia Helena Carvalho |
| author_facet | Taís Nóbrega de Sousa Flora Satiko Kano Cristiana Ferreira Alves de Brito Luzia Helena Carvalho |
| author_sort | Taís Nóbrega de Sousa |
| collection | DOAJ |
| description | Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania. |
| first_indexed | 2024-03-12T07:23:06Z |
| format | Article |
| id | doaj.art-3ce9bbe119ee4d8c91d40e983329c427 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:23:06Z |
| publishDate | 2014-08-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-3ce9bbe119ee4d8c91d40e983329c4272023-09-02T22:15:00ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602014-08-01109560861710.1590/0074-0276130592S0074-02762014000500608The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian AmazonTaís Nóbrega de SousaFlora Satiko KanoCristiana Ferreira Alves de BritoLuzia Helena CarvalhoPlasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500608&lng=en&tlng=enmalariaPlasmodium vivaxDuffy binding proteinnaturally acquired antibodiesgenetic variability |
| spellingShingle | Taís Nóbrega de Sousa Flora Satiko Kano Cristiana Ferreira Alves de Brito Luzia Helena Carvalho The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon Memorias do Instituto Oswaldo Cruz malaria Plasmodium vivax Duffy binding protein naturally acquired antibodies genetic variability |
| title | The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon |
| title_full | The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon |
| title_fullStr | The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon |
| title_full_unstemmed | The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon |
| title_short | The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon |
| title_sort | duffy binding protein as a key target for a plasmodium vivax vaccine lessons from the brazilian amazon |
| topic | malaria Plasmodium vivax Duffy binding protein naturally acquired antibodies genetic variability |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500608&lng=en&tlng=en |
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