Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review
Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies publi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2018-09-01
|
| Series: | Reviews in Clinical Medicine |
| Subjects: | |
| Online Access: | https://rcm.mums.ac.ir/article_10481_a3c1bc618f8ceeef9503f4835fa6b640.pdf |
| _version_ | 1828085800159412224 |
|---|---|
| author | Behnoush Bakhshoudeh Maryam Salehi Ramin Sadeghi Alireza Omranzadeh Toktam Sahranavard Soheil Arekhi Ali Jafarzadeh Esfehani Naghmeh Zabolinejad |
| author_facet | Behnoush Bakhshoudeh Maryam Salehi Ramin Sadeghi Alireza Omranzadeh Toktam Sahranavard Soheil Arekhi Ali Jafarzadeh Esfehani Naghmeh Zabolinejad |
| author_sort | Behnoush Bakhshoudeh |
| collection | DOAJ |
| description | Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies published after the last systematic review.Methods: We searched Scopus, PubMed, Embase, and ISI Web of Science. All the studies published during March 2012-June 2017 were included in this review. Two reviewers separately selected the studies and extracted the data. The results of studies were categorized as unimproved, stabilized, and improved based on the articles reports.Result: Among the 38 studies, 20, 17, and one studies assessed LPP, FFA, and both treatments, respectively. The papers were case reports, case series, cohorts, and randomized controlled trials. Antimalarial agents and pioglitazone resulted in enhancement in 73 and 71% of the LPP patients, respectively. Improvement and stabilization were observed in almost one third of the topical steroid users and 6/12 of Tacrolimus/Pimecrolimus users in LPP. Improvement and stabilization in FFA was found in 68% of the individuals using antimalarial agents, 83% of intralesional steroid users, all cases of finasteride users, and 95% of the people utilizing dutasteride.Conclusion: Contrary to the previous systematic review, we found antimalarial agents more effective than steroids in LPP. Finasteride/dutasteride may have favorable impacts on FFA. Intralesional steroids showed to be more effective than antimalarial agents in FFA. Still further studies are needed in order to define a treatment protocol. Low quality and heterogeneity of the articles were among the limitations for making a conclusion. |
| first_indexed | 2024-04-11T04:45:25Z |
| format | Article |
| id | doaj.art-3cea4484e2134849b4ea27614c1d4f03 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-04-11T04:45:25Z |
| publishDate | 2018-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-3cea4484e2134849b4ea27614c1d4f032022-12-27T13:07:20ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922018-09-0153769410.22038/rcm.2018.30338.122810481Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic ReviewBehnoush Bakhshoudeh0Maryam Salehi1Ramin Sadeghi2Alireza Omranzadeh3Toktam Sahranavard4Soheil Arekhi5Ali Jafarzadeh Esfehani6Naghmeh Zabolinejad7Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, IranAssociate Professor of Community Medicine, Research Center for Patient Safety, Mashhad University of Medical Science, Mashhad, Iran and Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranStudent of Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent of Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent of Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, IranCutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, IranIntroduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies published after the last systematic review.Methods: We searched Scopus, PubMed, Embase, and ISI Web of Science. All the studies published during March 2012-June 2017 were included in this review. Two reviewers separately selected the studies and extracted the data. The results of studies were categorized as unimproved, stabilized, and improved based on the articles reports.Result: Among the 38 studies, 20, 17, and one studies assessed LPP, FFA, and both treatments, respectively. The papers were case reports, case series, cohorts, and randomized controlled trials. Antimalarial agents and pioglitazone resulted in enhancement in 73 and 71% of the LPP patients, respectively. Improvement and stabilization were observed in almost one third of the topical steroid users and 6/12 of Tacrolimus/Pimecrolimus users in LPP. Improvement and stabilization in FFA was found in 68% of the individuals using antimalarial agents, 83% of intralesional steroid users, all cases of finasteride users, and 95% of the people utilizing dutasteride.Conclusion: Contrary to the previous systematic review, we found antimalarial agents more effective than steroids in LPP. Finasteride/dutasteride may have favorable impacts on FFA. Intralesional steroids showed to be more effective than antimalarial agents in FFA. Still further studies are needed in order to define a treatment protocol. Low quality and heterogeneity of the articles were among the limitations for making a conclusion.https://rcm.mums.ac.ir/article_10481_a3c1bc618f8ceeef9503f4835fa6b640.pdffrontal fibrosing alopecialichen planopilaristreatment |
| spellingShingle | Behnoush Bakhshoudeh Maryam Salehi Ramin Sadeghi Alireza Omranzadeh Toktam Sahranavard Soheil Arekhi Ali Jafarzadeh Esfehani Naghmeh Zabolinejad Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review Reviews in Clinical Medicine frontal fibrosing alopecia lichen planopilaris treatment |
| title | Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review |
| title_full | Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review |
| title_fullStr | Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review |
| title_full_unstemmed | Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review |
| title_short | Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review |
| title_sort | therapeutic updates on lichen planopilaris and frontal fibrosing alopecia a systematic review |
| topic | frontal fibrosing alopecia lichen planopilaris treatment |
| url | https://rcm.mums.ac.ir/article_10481_a3c1bc618f8ceeef9503f4835fa6b640.pdf |
| work_keys_str_mv | AT behnoushbakhshoudeh therapeuticupdatesonlichenplanopilarisandfrontalfibrosingalopeciaasystematicreview AT maryamsalehi therapeuticupdatesonlichenplanopilarisandfrontalfibrosingalopeciaasystematicreview AT raminsadeghi therapeuticupdatesonlichenplanopilarisandfrontalfibrosingalopeciaasystematicreview AT alirezaomranzadeh therapeuticupdatesonlichenplanopilarisandfrontalfibrosingalopeciaasystematicreview AT toktamsahranavard therapeuticupdatesonlichenplanopilarisandfrontalfibrosingalopeciaasystematicreview AT soheilarekhi therapeuticupdatesonlichenplanopilarisandfrontalfibrosingalopeciaasystematicreview AT alijafarzadehesfehani therapeuticupdatesonlichenplanopilarisandfrontalfibrosingalopeciaasystematicreview AT naghmehzabolinejad therapeuticupdatesonlichenplanopilarisandfrontalfibrosingalopeciaasystematicreview |