Nonimmune Hydrops Fetalis—Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review
The aim of this paper is to review the outcomes and discuss the genetic and non-genetic aetiology of nonimmune hydrops fetalis in order to support differential ultrasound and genetic evaluations and family counselling. This single-centre study includes all cases of nonimmune hydrops fetalis diagnose...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/6/1789 |
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| author | Przemyslaw Kosinski Pawel Krajewski Miroslaw Wielgos Aleksandra Jezela-Stanek |
| author_facet | Przemyslaw Kosinski Pawel Krajewski Miroslaw Wielgos Aleksandra Jezela-Stanek |
| author_sort | Przemyslaw Kosinski |
| collection | DOAJ |
| description | The aim of this paper is to review the outcomes and discuss the genetic and non-genetic aetiology of nonimmune hydrops fetalis in order to support differential ultrasound and genetic evaluations and family counselling. This single-centre study includes all cases of nonimmune hydrops fetalis diagnosed prenatally from 2009 to 2019. Two sources of data were used for this study (prenatal and neonatal) to compare and summarise the findings. Data from genetic testing and ultrasound scans were collected. In total, 33 pregnant women with prenatally diagnosed nonimmune hydrops fetalis were studied. The data included 30 cases of singleton (91%) and three cases (9%) of twin pregnancies. There were 14 survivors (43%), seven cases of postnatal deaths (21%), four cases of intrauterine foetal demises (12%), four cases of termination of pregnancy (12%), and four women without a follow up (12%). The total number of chromosomally normal singleton pregnancies was 29 (88%), and 14 foetuses had an anatomical abnormality detected on the ultrasound scan. The chance of survival was the highest in cases of isolated, idiopathic hydrops fetalis, which in most cases was due to an undetectable intrauterine infection. In many cases, the diagnosis could not be established throughout pregnancy. Each case of nonimmune hydrops fetalis should thus be analysed individually. |
| first_indexed | 2024-03-10T19:17:47Z |
| format | Article |
| id | doaj.art-3cea7c625eab4abd89769e90646360e0 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:17:47Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3cea7c625eab4abd89769e90646360e02023-11-20T03:13:37ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0196178910.3390/jcm9061789Nonimmune Hydrops Fetalis—Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature ReviewPrzemyslaw Kosinski0Pawel Krajewski1Miroslaw Wielgos2Aleksandra Jezela-Stanek31st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, PolandNeonatal Unit, 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, PolandDepartment of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, PolandThe aim of this paper is to review the outcomes and discuss the genetic and non-genetic aetiology of nonimmune hydrops fetalis in order to support differential ultrasound and genetic evaluations and family counselling. This single-centre study includes all cases of nonimmune hydrops fetalis diagnosed prenatally from 2009 to 2019. Two sources of data were used for this study (prenatal and neonatal) to compare and summarise the findings. Data from genetic testing and ultrasound scans were collected. In total, 33 pregnant women with prenatally diagnosed nonimmune hydrops fetalis were studied. The data included 30 cases of singleton (91%) and three cases (9%) of twin pregnancies. There were 14 survivors (43%), seven cases of postnatal deaths (21%), four cases of intrauterine foetal demises (12%), four cases of termination of pregnancy (12%), and four women without a follow up (12%). The total number of chromosomally normal singleton pregnancies was 29 (88%), and 14 foetuses had an anatomical abnormality detected on the ultrasound scan. The chance of survival was the highest in cases of isolated, idiopathic hydrops fetalis, which in most cases was due to an undetectable intrauterine infection. In many cases, the diagnosis could not be established throughout pregnancy. Each case of nonimmune hydrops fetalis should thus be analysed individually.https://www.mdpi.com/2077-0383/9/6/1789nonimmune foetal hydropsgenetic syndromesprenatal evaluationneonatal outcomes |
| spellingShingle | Przemyslaw Kosinski Pawel Krajewski Miroslaw Wielgos Aleksandra Jezela-Stanek Nonimmune Hydrops Fetalis—Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review Journal of Clinical Medicine nonimmune foetal hydrops genetic syndromes prenatal evaluation neonatal outcomes |
| title | Nonimmune Hydrops Fetalis—Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review |
| title_full | Nonimmune Hydrops Fetalis—Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review |
| title_fullStr | Nonimmune Hydrops Fetalis—Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review |
| title_full_unstemmed | Nonimmune Hydrops Fetalis—Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review |
| title_short | Nonimmune Hydrops Fetalis—Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review |
| title_sort | nonimmune hydrops fetalis prenatal diagnosis genetic investigation outcomes and literature review |
| topic | nonimmune foetal hydrops genetic syndromes prenatal evaluation neonatal outcomes |
| url | https://www.mdpi.com/2077-0383/9/6/1789 |
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