Conformational Variability in Ground-State CFTR Lipoprotein Particle Cryo-EM Ensembles

Conformational Variability in Ground-State CFTR Lipoprotein Particle Cryo-EM Ensembles

Cystic fibrosis transmembrane regulator (CFTR) is a dynamic membrane protein belonging to the ABC transporter family. It is unusual within this family as it is an ion channel, as opposed to a transporter. Activation of CFTR requires ATP and phosphorylation by PKA, and dysregulation of CFTR mediated...

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Bibliographic Details
Main Authors: Luba A. Aleksandrov, Adrei A. Aleksandrov, Timothy J. Jensen, Joshua D. Strauss, Jonathan F. Fay
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
cryo-EM
CFTR
cystic fibrosis
electrophysiology
SMALP
lipids
Online Access:https://www.mdpi.com/1422-0067/23/16/9248

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