Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling
Neurons release and respond to brain-derived neurotrophic factor (BDNF) with bursts of brain activity. BDNF action is known to extend to peri-synaptic astrocytes, contributing to synaptic strengthening. This implies that astrocytes have a set of dynamic responses, some of which might be secondary to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/9/1501 |
| _version_ | 1827672902462341120 |
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| author | Beatrice Vignoli Marco Canossa |
| author_facet | Beatrice Vignoli Marco Canossa |
| author_sort | Beatrice Vignoli |
| collection | DOAJ |
| description | Neurons release and respond to brain-derived neurotrophic factor (BDNF) with bursts of brain activity. BDNF action is known to extend to peri-synaptic astrocytes, contributing to synaptic strengthening. This implies that astrocytes have a set of dynamic responses, some of which might be secondary to activation of the tropomyosin tyrosine kinase B (TrkB) receptor. Here, we assessed the contribution of BDNF to long-term synaptic potentiation (LTP), by specifically deleting TrkB in cortical astrocytes. TrkB deletion had no effect on LTP induction, stabilization and maintenance, indicating that TrkB signaling in astrocytes is extraneous to transducing BDNF activity for synaptic strengthening. |
| first_indexed | 2024-03-10T04:15:49Z |
| format | Article |
| id | doaj.art-3cf07f51ece042c48e52e59d7a1f6ac8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:15:49Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3cf07f51ece042c48e52e59d7a1f6ac82023-11-23T08:00:05ZengMDPI AGCells2073-44092022-04-01119150110.3390/cells11091501Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB SignalingBeatrice Vignoli0Marco Canossa1Department of Physics, University of Trento, 38123 Povo (TN), ItalyDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Povo (TN), ItalyNeurons release and respond to brain-derived neurotrophic factor (BDNF) with bursts of brain activity. BDNF action is known to extend to peri-synaptic astrocytes, contributing to synaptic strengthening. This implies that astrocytes have a set of dynamic responses, some of which might be secondary to activation of the tropomyosin tyrosine kinase B (TrkB) receptor. Here, we assessed the contribution of BDNF to long-term synaptic potentiation (LTP), by specifically deleting TrkB in cortical astrocytes. TrkB deletion had no effect on LTP induction, stabilization and maintenance, indicating that TrkB signaling in astrocytes is extraneous to transducing BDNF activity for synaptic strengthening.https://www.mdpi.com/2073-4409/11/9/1501astrocyte microdomainssynaptic strengtheningneuron–astrocyte communication |
| spellingShingle | Beatrice Vignoli Marco Canossa Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling Cells astrocyte microdomains synaptic strengthening neuron–astrocyte communication |
| title | Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling |
| title_full | Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling |
| title_fullStr | Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling |
| title_full_unstemmed | Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling |
| title_short | Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling |
| title_sort | perirhinal cortex ltp does not require astrocyte bdnf trkb signaling |
| topic | astrocyte microdomains synaptic strengthening neuron–astrocyte communication |
| url | https://www.mdpi.com/2073-4409/11/9/1501 |
| work_keys_str_mv | AT beatricevignoli perirhinalcortexltpdoesnotrequireastrocytebdnftrkbsignaling AT marcocanossa perirhinalcortexltpdoesnotrequireastrocytebdnftrkbsignaling |