Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives
Multidisciplinary supportive care, integrating the dimensions of exercise alongside oncological treatments, is now regarded as a new paradigm to improve patient survival and quality of life. Its impact is important on the factors that control tumor development, such as the immune system, inflammatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/21/5402 |
| _version_ | 1797468771374333952 |
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| author | Cécile Torregrosa Frédéric Chorin Eva Ester Molina Beltran Cindy Neuzillet Victoire Cardot-Ruffino |
| author_facet | Cécile Torregrosa Frédéric Chorin Eva Ester Molina Beltran Cindy Neuzillet Victoire Cardot-Ruffino |
| author_sort | Cécile Torregrosa |
| collection | DOAJ |
| description | Multidisciplinary supportive care, integrating the dimensions of exercise alongside oncological treatments, is now regarded as a new paradigm to improve patient survival and quality of life. Its impact is important on the factors that control tumor development, such as the immune system, inflammation, tissue perfusion, hypoxia, insulin resistance, metabolism, glucocorticoid levels, and cachexia. An increasing amount of research has been published in the last years on the effects of physical activity within the framework of oncology, marking the appearance of a new medical field, commonly known as “exercise oncology”. This emerging research field is trying to determine the biological mechanisms by which, aerobic exercise affects the incidence of cancer, the progression and/or the appearance of metastases. We propose an overview of the current state of the art physical exercise interventions in the management of cancer patients, including a pragmatic perspective with tips for routine practice. We then develop the emerging mechanistic views about physical exercise and their potential clinical applications. Moving toward a more personalized, integrated, patient-centered, and multidisciplinary management, by trying to understand the different interactions between the cancer and the host, as well as the impact of the disease and the treatments on the different organs, this seems to be the most promising method to improve the care of cancer patients. |
| first_indexed | 2024-03-09T19:12:08Z |
| format | Article |
| id | doaj.art-3cf171b8079b4c5b96da34457b6db2f0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T19:12:08Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3cf171b8079b4c5b96da34457b6db2f02023-11-24T04:03:52ZengMDPI AGCancers2072-66942022-11-011421540210.3390/cancers14215402Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s PerspectivesCécile Torregrosa0Frédéric Chorin1Eva Ester Molina Beltran2Cindy Neuzillet3Victoire Cardot-Ruffino4Oncologie Digestive, Département d’Oncologie Médicale Institut Curie, Université Versailles Saint-Quentin—Université Paris Saclay, 35, rue Dailly, 92210 Saint-Cloud, FranceLaboratoire Motricité Humaine, Expertise, Sport, Santé (LAMHESS), HEALTHY Graduate School, Université Côte d’Azur, 06205 Nice, FranceOncologie Digestive, Département d’Oncologie Médicale Institut Curie, Université Versailles Saint-Quentin—Université Paris Saclay, 35, rue Dailly, 92210 Saint-Cloud, FranceOncologie Digestive, Département d’Oncologie Médicale Institut Curie, Université Versailles Saint-Quentin—Université Paris Saclay, 35, rue Dailly, 92210 Saint-Cloud, FranceDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USAMultidisciplinary supportive care, integrating the dimensions of exercise alongside oncological treatments, is now regarded as a new paradigm to improve patient survival and quality of life. Its impact is important on the factors that control tumor development, such as the immune system, inflammation, tissue perfusion, hypoxia, insulin resistance, metabolism, glucocorticoid levels, and cachexia. An increasing amount of research has been published in the last years on the effects of physical activity within the framework of oncology, marking the appearance of a new medical field, commonly known as “exercise oncology”. This emerging research field is trying to determine the biological mechanisms by which, aerobic exercise affects the incidence of cancer, the progression and/or the appearance of metastases. We propose an overview of the current state of the art physical exercise interventions in the management of cancer patients, including a pragmatic perspective with tips for routine practice. We then develop the emerging mechanistic views about physical exercise and their potential clinical applications. Moving toward a more personalized, integrated, patient-centered, and multidisciplinary management, by trying to understand the different interactions between the cancer and the host, as well as the impact of the disease and the treatments on the different organs, this seems to be the most promising method to improve the care of cancer patients.https://www.mdpi.com/2072-6694/14/21/5402physical activityexercisetrainingcancerimmunityinflammation |
| spellingShingle | Cécile Torregrosa Frédéric Chorin Eva Ester Molina Beltran Cindy Neuzillet Victoire Cardot-Ruffino Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives Cancers physical activity exercise training cancer immunity inflammation |
| title | Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives |
| title_full | Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives |
| title_fullStr | Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives |
| title_full_unstemmed | Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives |
| title_short | Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives |
| title_sort | physical activity as the best supportive care in cancer the clinician s and the researcher s perspectives |
| topic | physical activity exercise training cancer immunity inflammation |
| url | https://www.mdpi.com/2072-6694/14/21/5402 |
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