Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl 4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin

Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl 4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin

Abstract Despite rapid advances in both the early detection and treatment of cancer, the mortality from this disease remains high, which justifies the development of new products that are more selective and effective and have fewer side effects. Accordingly, a novel ester was synthesized that contai...

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Bibliographic Details
Main Authors: Rodrigo Juliano Oliveira, Fabrícia Paniago Ajala Nery Pereira, Ingridhy Ostaciana Maia Freitas da Silveira, Ricardo Vieira de Lima, Claudia Rodrigues Berno, João Renato Pesarini, Andréia Conceição Milan Brochado Antoniolli-Silva, Antônio Carlos Duenhas Monreal, Beatriz Adilson, Dênis Pires de Lima, Roberto da Silva Gomes
Format: Article
Language:English
Published: Sociedade Brasileira de Genética
Series:Genetics and Molecular Biology
Subjects:
Cancer
4-aminoantipyrine
1,4-dioxo-butenyl
chemoprevention
chemotherapy
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019005025101&lng=en&tlng=en

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