Comparative Study of Methods for Cycle Length Estimation in Fractionated Electrograms of Atrial Fibrillation
Atrial cycle length (CL) is an important feature for the analysis of electrogram (EGM) characteristics acquired during catheter ablation (CA) of atrial fibrillation (AF), the commonest cardiac arrhythmia. Nevertheless, a robust ACL estimator requires the precise detection of local activation waves (...
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MDPI AG
2022-10-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/10/1712 |
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| author | Diego Osorio Aikaterini Vraka José Moreno-Arribas Vicente Bertomeu-González Raúl Alcaraz José J. Rieta |
| author_facet | Diego Osorio Aikaterini Vraka José Moreno-Arribas Vicente Bertomeu-González Raúl Alcaraz José J. Rieta |
| author_sort | Diego Osorio |
| collection | DOAJ |
| description | Atrial cycle length (CL) is an important feature for the analysis of electrogram (EGM) characteristics acquired during catheter ablation (CA) of atrial fibrillation (AF), the commonest cardiac arrhythmia. Nevertheless, a robust ACL estimator requires the precise detection of local activation waves (LAWs), which still remains a challenge. This work aims to compare the performance in (CL) estimation, especially under fractionated EGMs, of three different LAW detection methods relying on different operation strategies. The methods are based on the hyperbolic tangent (HT) function, an adaptive amplitude threshold (AAT) and a (CL) iteration (ACLI), respectively. For each method, LAW detection has been assessed with respect to manual annotations made by two experts and performance has been estimated by confusion matrix and mean and individual (CL) error calculation by EGM types of fractionation. The influence of EGM length on the individual (CL) error has been additionally considered. For the HT method, accuracy, sensitivity and precision were 92.77–100%, while for the AAT and ACLI methods they were 78.89–99.91% for all EGM types. The CL error on the HT method was lower than AAT and ACLI methods (up to 12 ms versus up to 20 ms), with the difference being more prominent in complex EGMs. The HT method also showed the lowest dependency on EGM length, presenting the lowest and least variable error values. Therefore, the HT method achieves higher performance in (CL) estimation in comparison with previous LAW detection techniques. The high robustness and precision demonstrated by this method suggest its implementation on CA mapping devices for a more successful location of ablation targets and improved results during CA procedures. |
| first_indexed | 2024-03-09T19:57:50Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T19:57:50Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-3cf1a8d21d1e40b486bf5f2e3bc6eb742023-11-24T00:50:45ZengMDPI AGJournal of Personalized Medicine2075-44262022-10-011210171210.3390/jpm12101712Comparative Study of Methods for Cycle Length Estimation in Fractionated Electrograms of Atrial FibrillationDiego Osorio0Aikaterini Vraka1José Moreno-Arribas2Vicente Bertomeu-González3Raúl Alcaraz4José J. Rieta5BioMIT.org, Electronic Engineering Department, Universitat Politecnica de Valencia, 46022 Valencia, SpainBioMIT.org, Electronic Engineering Department, Universitat Politecnica de Valencia, 46022 Valencia, SpainCardiology Department, Saint John’s University Hospital, 03550 Alicante, SpainCardiology Department, Saint John’s University Hospital, 03550 Alicante, SpainResearch Group in Electronic, Biomedical and Telecommunication Engineering, University of Castilla-La Mancha, 16071 Cuenca, SpainBioMIT.org, Electronic Engineering Department, Universitat Politecnica de Valencia, 46022 Valencia, SpainAtrial cycle length (CL) is an important feature for the analysis of electrogram (EGM) characteristics acquired during catheter ablation (CA) of atrial fibrillation (AF), the commonest cardiac arrhythmia. Nevertheless, a robust ACL estimator requires the precise detection of local activation waves (LAWs), which still remains a challenge. This work aims to compare the performance in (CL) estimation, especially under fractionated EGMs, of three different LAW detection methods relying on different operation strategies. The methods are based on the hyperbolic tangent (HT) function, an adaptive amplitude threshold (AAT) and a (CL) iteration (ACLI), respectively. For each method, LAW detection has been assessed with respect to manual annotations made by two experts and performance has been estimated by confusion matrix and mean and individual (CL) error calculation by EGM types of fractionation. The influence of EGM length on the individual (CL) error has been additionally considered. For the HT method, accuracy, sensitivity and precision were 92.77–100%, while for the AAT and ACLI methods they were 78.89–99.91% for all EGM types. The CL error on the HT method was lower than AAT and ACLI methods (up to 12 ms versus up to 20 ms), with the difference being more prominent in complex EGMs. The HT method also showed the lowest dependency on EGM length, presenting the lowest and least variable error values. Therefore, the HT method achieves higher performance in (CL) estimation in comparison with previous LAW detection techniques. The high robustness and precision demonstrated by this method suggest its implementation on CA mapping devices for a more successful location of ablation targets and improved results during CA procedures.https://www.mdpi.com/2075-4426/12/10/1712atrial fibrillationelectrogramcomplex fractionated atrial electrogramslocal activation wavesdetectioninvasive recordings |
| spellingShingle | Diego Osorio Aikaterini Vraka José Moreno-Arribas Vicente Bertomeu-González Raúl Alcaraz José J. Rieta Comparative Study of Methods for Cycle Length Estimation in Fractionated Electrograms of Atrial Fibrillation Journal of Personalized Medicine atrial fibrillation electrogram complex fractionated atrial electrograms local activation waves detection invasive recordings |
| title | Comparative Study of Methods for Cycle Length Estimation in Fractionated Electrograms of Atrial Fibrillation |
| title_full | Comparative Study of Methods for Cycle Length Estimation in Fractionated Electrograms of Atrial Fibrillation |
| title_fullStr | Comparative Study of Methods for Cycle Length Estimation in Fractionated Electrograms of Atrial Fibrillation |
| title_full_unstemmed | Comparative Study of Methods for Cycle Length Estimation in Fractionated Electrograms of Atrial Fibrillation |
| title_short | Comparative Study of Methods for Cycle Length Estimation in Fractionated Electrograms of Atrial Fibrillation |
| title_sort | comparative study of methods for cycle length estimation in fractionated electrograms of atrial fibrillation |
| topic | atrial fibrillation electrogram complex fractionated atrial electrograms local activation waves detection invasive recordings |
| url | https://www.mdpi.com/2075-4426/12/10/1712 |
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