Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury?
Transplants comprised of encapsulated islets have shown promise in treating insulin-dependent diabetes. A question raised in the scientific and clinical communities is whether the insulin released from an implanted encapsulation device damaged in an accident could cause a serious hypoglycemic event....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-04-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897231163233 |
| _version_ | 1827974414934736896 |
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| author | Klearchos K. Papas Charles W. Putnam Robert C. Johnson Athanassios Sambanis |
| author_facet | Klearchos K. Papas Charles W. Putnam Robert C. Johnson Athanassios Sambanis |
| author_sort | Klearchos K. Papas |
| collection | DOAJ |
| description | Transplants comprised of encapsulated islets have shown promise in treating insulin-dependent diabetes. A question raised in the scientific and clinical communities is whether the insulin released from an implanted encapsulation device damaged in an accident could cause a serious hypoglycemic event. In this commentary, we consider the different types of damage that a device can sustain, including the encapsulation membrane and the islets within, and the amount of insulin released in each case. We conclude that the probability that device damage would cause an adverse hypoglycemic event is indeed very low. |
| first_indexed | 2024-04-09T19:54:00Z |
| format | Article |
| id | doaj.art-3cf2d8519b374dd1b1d4b8aa58a13cb3 |
| institution | Directory Open Access Journal |
| issn | 1555-3892 |
| language | English |
| last_indexed | 2024-04-09T19:54:00Z |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-3cf2d8519b374dd1b1d4b8aa58a13cb32023-04-03T05:33:37ZengSAGE PublishingCell Transplantation1555-38922023-04-013210.1177/09636897231163233Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury?Klearchos K. Papas0Charles W. Putnam1Robert C. Johnson2Athanassios Sambanis3Procyon Technologies LLC, Tucson, AZ, USAInstitute for Cellular Transplantation, University of Arizona, Tucson, AZ, USAProcyon Technologies LLC, Tucson, AZ, USAGeorgia Institute of Technology, Atlanta, GA, USATransplants comprised of encapsulated islets have shown promise in treating insulin-dependent diabetes. A question raised in the scientific and clinical communities is whether the insulin released from an implanted encapsulation device damaged in an accident could cause a serious hypoglycemic event. In this commentary, we consider the different types of damage that a device can sustain, including the encapsulation membrane and the islets within, and the amount of insulin released in each case. We conclude that the probability that device damage would cause an adverse hypoglycemic event is indeed very low.https://doi.org/10.1177/09636897231163233 |
| spellingShingle | Klearchos K. Papas Charles W. Putnam Robert C. Johnson Athanassios Sambanis Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury? Cell Transplantation |
| title | Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury? |
| title_full | Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury? |
| title_fullStr | Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury? |
| title_full_unstemmed | Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury? |
| title_short | Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury? |
| title_sort | encapsulated cells for the treatment of diabetes danger of acute hypoglycemia following injury |
| url | https://doi.org/10.1177/09636897231163233 |
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