Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit
Purpose In this study, we investigated the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients. Methods A retrospective analysis was conducted on medical records from January 2010 to June 2017 (7.5 years) of a university hospital NICU....
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2019-01-01
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| Series: | Korean Journal of Pediatrics |
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| Online Access: | http://www.kjp.or.kr/upload/pdf/kjp-2018-06807.pdf |
| _version_ | 1828372718449328128 |
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| author | Se Jin Kim Ga Eun Kim Jae Hyun Park Sang Lak Lee Chun Soo Kim |
| author_facet | Se Jin Kim Ga Eun Kim Jae Hyun Park Sang Lak Lee Chun Soo Kim |
| author_sort | Se Jin Kim |
| collection | DOAJ |
| description | Purpose In this study, we investigated the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients. Methods A retrospective analysis was conducted on medical records from January 2010 to June 2017 (7.5 years) of a university hospital NICU. Results There were 45 cases of EOS (1.2%) in 3,862 infants. The most common pathogen responsible for EOS was group B Streptococcus (GBS), implicated in 10 cases (22.2%), followed by Escherichia coli, implicated in 9 cases (20%). The frequency of gram-positive sepsis was higher in term than in preterm infants, whereas the rate of gram-negative infection was higher in preterm than in term infants (P<0.05). The overall mortality was 37.8% (17 of 45), and 47% of deaths occurred within the first 3 days of infection. There were significant differences in terms of gestational age (26.8 weeks vs. 35.1 weeks) and birth weight (957 g vs. 2,520 g) between the death and survival groups. After adjustments based on the difference in gestational age and birth weight between the 2 groups, gram-negative pathogens (odds ratio [OR], 42; 95% confidence interval [CI], 1.4–1,281.8) and some clinical findings, such as neutropenia (OR, 46; 95% CI, 1.3–1,628.7) and decreased activity (OR, 34; 95% CI, 1.8–633.4), were found to be associated with fatality. Conclusion The common pathogens found to be responsible for EOS in NICU patients are GBS and E. coli. Gram-negative bacterial infections, decreased activity in the early phase of infection, and neutropenia were associated with poor outcomes. |
| first_indexed | 2024-04-14T07:08:02Z |
| format | Article |
| id | doaj.art-3cf3551eb55346498f87ad57ec47ab61 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-04-14T07:08:02Z |
| publishDate | 2019-01-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-3cf3551eb55346498f87ad57ec47ab612022-12-22T02:06:31ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582019-01-01621364110.3345/kjp.2018.0680720125553479Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unitSe Jin Kim0Ga Eun Kim1Jae Hyun Park2Sang Lak Lee3Chun Soo Kim4 Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea Department of Pediatrics, Keimyung University School of Medicine, Daegu, KoreaPurpose In this study, we investigated the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients. Methods A retrospective analysis was conducted on medical records from January 2010 to June 2017 (7.5 years) of a university hospital NICU. Results There were 45 cases of EOS (1.2%) in 3,862 infants. The most common pathogen responsible for EOS was group B Streptococcus (GBS), implicated in 10 cases (22.2%), followed by Escherichia coli, implicated in 9 cases (20%). The frequency of gram-positive sepsis was higher in term than in preterm infants, whereas the rate of gram-negative infection was higher in preterm than in term infants (P<0.05). The overall mortality was 37.8% (17 of 45), and 47% of deaths occurred within the first 3 days of infection. There were significant differences in terms of gestational age (26.8 weeks vs. 35.1 weeks) and birth weight (957 g vs. 2,520 g) between the death and survival groups. After adjustments based on the difference in gestational age and birth weight between the 2 groups, gram-negative pathogens (odds ratio [OR], 42; 95% confidence interval [CI], 1.4–1,281.8) and some clinical findings, such as neutropenia (OR, 46; 95% CI, 1.3–1,628.7) and decreased activity (OR, 34; 95% CI, 1.8–633.4), were found to be associated with fatality. Conclusion The common pathogens found to be responsible for EOS in NICU patients are GBS and E. coli. Gram-negative bacterial infections, decreased activity in the early phase of infection, and neutropenia were associated with poor outcomes.http://www.kjp.or.kr/upload/pdf/kjp-2018-06807.pdfearly-onset sepsisclinical featuresprognosisneonatal intensive care unit |
| spellingShingle | Se Jin Kim Ga Eun Kim Jae Hyun Park Sang Lak Lee Chun Soo Kim Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit Korean Journal of Pediatrics early-onset sepsis clinical features prognosis neonatal intensive care unit |
| title | Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit |
| title_full | Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit |
| title_fullStr | Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit |
| title_full_unstemmed | Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit |
| title_short | Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit |
| title_sort | clinical features and prognostic factors of early onset sepsis a 7 5 year experience in one neonatal intensive care unit |
| topic | early-onset sepsis clinical features prognosis neonatal intensive care unit |
| url | http://www.kjp.or.kr/upload/pdf/kjp-2018-06807.pdf |
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