New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells
Abstract Metastasis is the primary cause of death in lung cancer patients. However, until now, effective drugs and intervention strategies for treating lung cancer metastasis have been lacking. This hypothesis focuses on circulating tumour cells (CTCs) to develop a new antimetastatic therapeutic str...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02782-w |
| _version_ | 1797984045660897280 |
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| author | Zujun Que Jianhui Tian |
| author_facet | Zujun Que Jianhui Tian |
| author_sort | Zujun Que |
| collection | DOAJ |
| description | Abstract Metastasis is the primary cause of death in lung cancer patients. However, until now, effective drugs and intervention strategies for treating lung cancer metastasis have been lacking. This hypothesis focuses on circulating tumour cells (CTCs) to develop a new antimetastatic therapeutic strategy for lung cancer. Here, we outline the role of CTCs in tumour metastasis and their functional effects during the treatment of lung cancer patients. Additionally, we hypothesized the possibility of CTCs as a novel biomarker and therapeutic target in preventing and treating metastasis in patients with early-stage lung cancer. We hope that the realization of this hypothesis will improve the overall survival of lung cancer. |
| first_indexed | 2024-04-11T06:56:31Z |
| format | Article |
| id | doaj.art-3cf90a943dc04013a635a3c9dd6bdc1e |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-11T06:56:31Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-3cf90a943dc04013a635a3c9dd6bdc1e2022-12-22T04:39:01ZengBMCCancer Cell International1475-28672022-11-012211410.1186/s12935-022-02782-wNew strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cellsZujun Que0Jianhui Tian1Institute of Oncology, Shanghai Municipal Hospital of TCM, Shanghai University of Traditional Chinese Medicine (TCM)Institute of Oncology, Shanghai Municipal Hospital of TCM, Shanghai University of Traditional Chinese Medicine (TCM)Abstract Metastasis is the primary cause of death in lung cancer patients. However, until now, effective drugs and intervention strategies for treating lung cancer metastasis have been lacking. This hypothesis focuses on circulating tumour cells (CTCs) to develop a new antimetastatic therapeutic strategy for lung cancer. Here, we outline the role of CTCs in tumour metastasis and their functional effects during the treatment of lung cancer patients. Additionally, we hypothesized the possibility of CTCs as a novel biomarker and therapeutic target in preventing and treating metastasis in patients with early-stage lung cancer. We hope that the realization of this hypothesis will improve the overall survival of lung cancer.https://doi.org/10.1186/s12935-022-02782-wLung cancerCirculating tumour cellsAntimetastaticTherapeutic strategyBiomarker |
| spellingShingle | Zujun Que Jianhui Tian New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells Cancer Cell International Lung cancer Circulating tumour cells Antimetastatic Therapeutic strategy Biomarker |
| title | New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells |
| title_full | New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells |
| title_fullStr | New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells |
| title_full_unstemmed | New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells |
| title_short | New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells |
| title_sort | new strategy for antimetastatic treatment of lung cancer a hypothesis based on circulating tumour cells |
| topic | Lung cancer Circulating tumour cells Antimetastatic Therapeutic strategy Biomarker |
| url | https://doi.org/10.1186/s12935-022-02782-w |
| work_keys_str_mv | AT zujunque newstrategyforantimetastatictreatmentoflungcancerahypothesisbasedoncirculatingtumourcells AT jianhuitian newstrategyforantimetastatictreatmentoflungcancerahypothesisbasedoncirculatingtumourcells |