A Multiscale Approach for the Characterization and Crystallization of Eflucimibe Polymorphs: from Molecules to Particles
We present in this paper a generic multiscale methodology for the characterization and crystallization of eflucimibe polymorphs. The various characterization techniques used have shown that eflucimibe polymorphism is due to a conformational ch...
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| Format: | Article |
| Language: | English |
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Hosokawa Powder Technology Foundation
2014-03-01
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| Series: | KONA Powder and Particle Journal |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/kona/29/0/29_2011026/_pdf/-char/en |
| _version_ | 1818459022821425152 |
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| author | Sébastien Teychené Béatrice Biscans |
| author_facet | Sébastien Teychené Béatrice Biscans |
| author_sort | Sébastien Teychené |
| collection | DOAJ |
| description | We present in this paper a generic multiscale methodology for the characterization and crystallization of eflucimibe polymorphs. The various characterization techniques used have shown that eflucimibe polymorphism is due to a conformational change of the molecule in the crystal lattice. In addition, the two polymorphs are monotropically related in the temperature range tested and have similar structures and properties (i.e. interfacial tension and solubility). Consequently, it was found that for a wide range of operating conditions, the polymorphs may crystallize concomitantly. Induction time measurements and metastable zone width determination allow to infer the origin of the concomitant appearance of the polymorphs. A predominance diagram has been established which allows to perfectly control the crystallization of the desired polymorph. However, even if the stable form can be produced in a reliable way, the crystal suspension went toward a very structured gel-like network which limits the extrapolation process. Based on microscopic observation of the crystallization events performed in a microfluidic crystallizer, we propose a range of operating conditions suitable for the production of the stable form with the desired handling properties. |
| first_indexed | 2024-12-14T23:07:45Z |
| format | Article |
| id | doaj.art-3cfa2cc4010a4d43b4e21746622ebe73 |
| institution | Directory Open Access Journal |
| issn | 0288-4534 2187-5537 |
| language | English |
| last_indexed | 2024-12-14T23:07:45Z |
| publishDate | 2014-03-01 |
| publisher | Hosokawa Powder Technology Foundation |
| record_format | Article |
| series | KONA Powder and Particle Journal |
| spelling | doaj.art-3cfa2cc4010a4d43b4e21746622ebe732022-12-21T22:44:17ZengHosokawa Powder Technology FoundationKONA Powder and Particle Journal0288-45342187-55372014-03-0129026628210.14356/kona.2011026konaA Multiscale Approach for the Characterization and Crystallization of Eflucimibe Polymorphs: from Molecules to ParticlesSébastien Teychené0Béatrice Biscans1Laboratoire de Génie Chimique UMR CNRS 5503, Université de ToulouseLaboratoire de Génie Chimique UMR CNRS 5503, Université de ToulouseWe present in this paper a generic multiscale methodology for the characterization and crystallization of eflucimibe polymorphs. The various characterization techniques used have shown that eflucimibe polymorphism is due to a conformational change of the molecule in the crystal lattice. In addition, the two polymorphs are monotropically related in the temperature range tested and have similar structures and properties (i.e. interfacial tension and solubility). Consequently, it was found that for a wide range of operating conditions, the polymorphs may crystallize concomitantly. Induction time measurements and metastable zone width determination allow to infer the origin of the concomitant appearance of the polymorphs. A predominance diagram has been established which allows to perfectly control the crystallization of the desired polymorph. However, even if the stable form can be produced in a reliable way, the crystal suspension went toward a very structured gel-like network which limits the extrapolation process. Based on microscopic observation of the crystallization events performed in a microfluidic crystallizer, we propose a range of operating conditions suitable for the production of the stable form with the desired handling properties.https://www.jstage.jst.go.jp/article/kona/29/0/29_2011026/_pdf/-char/encrystallizationrheologymicrofluidicpolymorphismnucleation |
| spellingShingle | Sébastien Teychené Béatrice Biscans A Multiscale Approach for the Characterization and Crystallization of Eflucimibe Polymorphs: from Molecules to Particles KONA Powder and Particle Journal crystallization rheology microfluidic polymorphism nucleation |
| title | A Multiscale Approach for the Characterization and Crystallization of Eflucimibe Polymorphs: from Molecules to Particles |
| title_full | A Multiscale Approach for the Characterization and Crystallization of Eflucimibe Polymorphs: from Molecules to Particles |
| title_fullStr | A Multiscale Approach for the Characterization and Crystallization of Eflucimibe Polymorphs: from Molecules to Particles |
| title_full_unstemmed | A Multiscale Approach for the Characterization and Crystallization of Eflucimibe Polymorphs: from Molecules to Particles |
| title_short | A Multiscale Approach for the Characterization and Crystallization of Eflucimibe Polymorphs: from Molecules to Particles |
| title_sort | multiscale approach for the characterization and crystallization of eflucimibe polymorphs from molecules to particles |
| topic | crystallization rheology microfluidic polymorphism nucleation |
| url | https://www.jstage.jst.go.jp/article/kona/29/0/29_2011026/_pdf/-char/en |
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