The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea
Rosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtuall...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2019.00324/full |
| _version_ | 1819051092065910784 |
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| author | Lian Wang Yu-Jia Wang Yu-Jia Wang Dan Hao Xiang Wen Dan Du Gu He Gu He Xian Jiang |
| author_facet | Lian Wang Yu-Jia Wang Yu-Jia Wang Dan Hao Xiang Wen Dan Du Gu He Gu He Xian Jiang |
| author_sort | Lian Wang |
| collection | DOAJ |
| description | Rosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea. In this review article, we describe recent advances of skin mast cells in the development of rosacea. These studies suggested that mast cells can be an important immune cell that connected innate immunity, nerves, and blood vessels in the development of rosacea. Moreover, we review the inhibition of mast cells for the potential treatment of rosacea. |
| first_indexed | 2024-12-21T11:58:26Z |
| format | Article |
| id | doaj.art-3cfd8e3194fe44e6aa95f76f202e9962 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-21T11:58:26Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3cfd8e3194fe44e6aa95f76f202e99622022-12-21T19:04:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-01-01610.3389/fmed.2019.00324503002The Theranostics Role of Mast Cells in the Pathophysiology of RosaceaLian Wang0Yu-Jia Wang1Yu-Jia Wang2Dan Hao3Xiang Wen4Dan Du5Gu He6Gu He7Xian Jiang8Department of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, ChinaRosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea. In this review article, we describe recent advances of skin mast cells in the development of rosacea. These studies suggested that mast cells can be an important immune cell that connected innate immunity, nerves, and blood vessels in the development of rosacea. Moreover, we review the inhibition of mast cells for the potential treatment of rosacea.https://www.frontiersin.org/article/10.3389/fmed.2019.00324/fullmast cellrosaceapathophysiologytreatmentdermatology |
| spellingShingle | Lian Wang Yu-Jia Wang Yu-Jia Wang Dan Hao Xiang Wen Dan Du Gu He Gu He Xian Jiang The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea Frontiers in Medicine mast cell rosacea pathophysiology treatment dermatology |
| title | The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea |
| title_full | The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea |
| title_fullStr | The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea |
| title_full_unstemmed | The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea |
| title_short | The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea |
| title_sort | theranostics role of mast cells in the pathophysiology of rosacea |
| topic | mast cell rosacea pathophysiology treatment dermatology |
| url | https://www.frontiersin.org/article/10.3389/fmed.2019.00324/full |
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