Methylene tetrahydrofolate reductase gene mutation in sickle cell anaemia patients in Lagos, Nigeria

Methylene tetrahydrofolate reductase gene mutation in sickle cell anaemia patients in Lagos, Nigeria

INTRODUCTION: The significant causes of mortality among individuals with sickle cell anaemia (SCA) such as acute chest syndrome and cerebrovascular disease are related to vascular occlusion. Polymorphisms of the methylene tetrahydrofolate reductase (MTHFR) gene in persons with sickle cell anaemia ha...

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Bibliographic Details
Main Authors: Oluwaseun Olabisi Adelekan, Ebele Ifeyinwa Uche, Taiwo Modupe Balogun, Vincent Oluseye Osunkalu, Akinsegun Abduljaleel Akinbami, Kamal Ayobami Ismail, Mulikat Adesola Badiru, Adedoyin Owolabi Dosunmu, Omolara Risqat Kamson
Format: Article
Language:English
Published: The Pan African Medical Journal 2019-12-01
Series:The Pan African Medical Journal
Subjects:
sickle cell anaemia
methylene tetrahydrofolate reductase gene mutation
c677t
a1298c
Online Access: https://www.panafrican-med-journal.com/content/article/34/213/pdf/213.pdf
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Summary:INTRODUCTION: The significant causes of mortality among individuals with sickle cell anaemia (SCA) such as acute chest syndrome and cerebrovascular disease are related to vascular occlusion. Polymorphisms of the methylene tetrahydrofolate reductase (MTHFR) gene in persons with sickle cell anaemia have been suggested as a potential risk for vaso-occlusive events, with the C677T and A1298C polymorphisms being the commonest. This study therefore aimed to establish the pattern of MTHFR C677T and A1298C gene mutations among adults with HbSS phenotype attending the Haematology Clinic in Lagos State University Teaching Hospital Lagos, Nigeria.
ISSN:1937-8688
1937-8688

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