Interrelationship of βeta-2 microglobulin, blood urea nitrogen and creatinine in streptozotocin -induced diabetes mellitus in rabbits
Measurement of serum creatinine (Cr) and blood urea nitrogen (BUN) are used as indicators of glomerular filtration rate. The increased levels of these biomarkers are usually detectable at advanced stages of kidney complications. The aim of this study was to find the interrelationship of beta-2 micro...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Urmia University
2013-12-01
|
| Series: | Veterinary Research Forum |
| Subjects: | |
| Online Access: | http://www.urmia.ac.ir/vrf/Shared%20Documents/pdf/vol-5%20no-1/7-11-0297.pdf |
| _version_ | 1818243550343593984 |
|---|---|
| author | Shahram Javadi Siamak Asri-Rezaei Maryam Allahverdizadeh |
| author_facet | Shahram Javadi Siamak Asri-Rezaei Maryam Allahverdizadeh |
| author_sort | Shahram Javadi |
| collection | DOAJ |
| description | Measurement of serum creatinine (Cr) and blood urea nitrogen (BUN) are used as indicators of glomerular filtration rate. The increased levels of these biomarkers are usually detectable at advanced stages of kidney complications. The aim of this study was to find the interrelationship of beta-2 microglobulin (β2M), BUN and Cr in streptozotocin (STZ)-induced diabetes mellitus in rabbits. Diabetes was induced by a single intraperitoneal (IP) injection of 65 mg kg-1 of STZ in rabbits. The levels of serum insulin, glucose and three above mentioned biomarkers were measured one day before (day -1) and on days 1-3 after injection of STZ and continued weekly to the end of the experiment (12 weeks). A statistically significant increase of serum β2M, BUN, Cr and glucose levels, and a significant decrease of insulin levels were observed in diabetic animals. However, β2M levels increased as early as one day after STZ injection compared to Cr and BUN that elevated at day two, suggesting a probable diagnostic advantage of β2M over currently used biomarkers in diabetic related kidney complications. |
| first_indexed | 2024-12-12T14:02:54Z |
| format | Article |
| id | doaj.art-3cff51dfac5d45109f531c1d9e252478 |
| institution | Directory Open Access Journal |
| issn | 2008-8140 |
| language | English |
| last_indexed | 2024-12-12T14:02:54Z |
| publishDate | 2013-12-01 |
| publisher | Urmia University |
| record_format | Article |
| series | Veterinary Research Forum |
| spelling | doaj.art-3cff51dfac5d45109f531c1d9e2524782022-12-22T00:22:17ZengUrmia UniversityVeterinary Research Forum2008-81402013-12-0151711Interrelationship of βeta-2 microglobulin, blood urea nitrogen and creatinine in streptozotocin -induced diabetes mellitus in rabbitsShahram Javadi0Siamak Asri-Rezaei1Maryam Allahverdizadeh2Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, IranShahram Javadi ; Siamak Asri-Rezaei; Maryam Allahverdizadeh Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, IranShahram Javadi ; Siamak Asri-Rezaei; Maryam Allahverdizadeh Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, IranMeasurement of serum creatinine (Cr) and blood urea nitrogen (BUN) are used as indicators of glomerular filtration rate. The increased levels of these biomarkers are usually detectable at advanced stages of kidney complications. The aim of this study was to find the interrelationship of beta-2 microglobulin (β2M), BUN and Cr in streptozotocin (STZ)-induced diabetes mellitus in rabbits. Diabetes was induced by a single intraperitoneal (IP) injection of 65 mg kg-1 of STZ in rabbits. The levels of serum insulin, glucose and three above mentioned biomarkers were measured one day before (day -1) and on days 1-3 after injection of STZ and continued weekly to the end of the experiment (12 weeks). A statistically significant increase of serum β2M, BUN, Cr and glucose levels, and a significant decrease of insulin levels were observed in diabetic animals. However, β2M levels increased as early as one day after STZ injection compared to Cr and BUN that elevated at day two, suggesting a probable diagnostic advantage of β2M over currently used biomarkers in diabetic related kidney complications.http://www.urmia.ac.ir/vrf/Shared%20Documents/pdf/vol-5%20no-1/7-11-0297.pdfΒeta-2 microglobulin; Diabetes Mellitus; Streptozotocin |
| spellingShingle | Shahram Javadi Siamak Asri-Rezaei Maryam Allahverdizadeh Interrelationship of βeta-2 microglobulin, blood urea nitrogen and creatinine in streptozotocin -induced diabetes mellitus in rabbits Veterinary Research Forum Βeta-2 microglobulin; Diabetes Mellitus; Streptozotocin |
| title | Interrelationship of βeta-2 microglobulin, blood urea nitrogen and creatinine in streptozotocin -induced diabetes mellitus in rabbits |
| title_full | Interrelationship of βeta-2 microglobulin, blood urea nitrogen and creatinine in streptozotocin -induced diabetes mellitus in rabbits |
| title_fullStr | Interrelationship of βeta-2 microglobulin, blood urea nitrogen and creatinine in streptozotocin -induced diabetes mellitus in rabbits |
| title_full_unstemmed | Interrelationship of βeta-2 microglobulin, blood urea nitrogen and creatinine in streptozotocin -induced diabetes mellitus in rabbits |
| title_short | Interrelationship of βeta-2 microglobulin, blood urea nitrogen and creatinine in streptozotocin -induced diabetes mellitus in rabbits |
| title_sort | interrelationship of βeta 2 microglobulin blood urea nitrogen and creatinine in streptozotocin induced diabetes mellitus in rabbits |
| topic | Βeta-2 microglobulin; Diabetes Mellitus; Streptozotocin |
| url | http://www.urmia.ac.ir/vrf/Shared%20Documents/pdf/vol-5%20no-1/7-11-0297.pdf |
| work_keys_str_mv | AT shahramjavadi interrelationshipofbeta2microglobulinbloodureanitrogenandcreatinineinstreptozotocininduceddiabetesmellitusinrabbits AT siamakasrirezaei interrelationshipofbeta2microglobulinbloodureanitrogenandcreatinineinstreptozotocininduceddiabetesmellitusinrabbits AT maryamallahverdizadeh interrelationshipofbeta2microglobulinbloodureanitrogenandcreatinineinstreptozotocininduceddiabetesmellitusinrabbits |