Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water
Biocompatible amphiphilic statistical copolymers P(MEA/MPC<i><sub>m</sub></i>) composed of 2-methoxyethyl acrylate (MEA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared with three different mol% of the hydrophilic unit MPC (<i>m</i> = 6, 12 and 46...
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MDPI AG
2020-08-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/8/1808 |
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| author | Thi Lien Nguyen Yuuki Kawata Kazuhiko Ishihara Shin-ichi Yusa |
| author_facet | Thi Lien Nguyen Yuuki Kawata Kazuhiko Ishihara Shin-ichi Yusa |
| author_sort | Thi Lien Nguyen |
| collection | DOAJ |
| description | Biocompatible amphiphilic statistical copolymers P(MEA/MPC<i><sub>m</sub></i>) composed of 2-methoxyethyl acrylate (MEA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared with three different mol% of the hydrophilic unit MPC (<i>m</i> = 6, 12 and 46 mol%). The monomer reactivity ratios of MEA (<i>r</i><sub>MEA</sub>) and MPC (<i>r</i><sub>MPC</sub>) were 0.53 and 2.21, respectively. The <i>r</i><sub>MEA</sub> × <i>r</i><sub>MPC</sub> value of 1.17 demonstrated that statistical copolymerization was successful. P(MEA/MPC<sub>12</sub>) and P(MEA/MPC<sub>46</sub>) copolymers did not undergo aggregation in water, whereas the P(MEA/MPC<sub>6</sub>) copolymer formed micelles in water with a hydrodynamic radius (<i>R</i><sub>h</sub>) of 96.9 nm and a critical aggregation concentration, which was determined using pyrene fluorescence, at 0.0082 g/L. The restricted motion of the protons in the hydrophobic MEA units in the micelles’ cores provided additional evidence of self-association in P(MEA/MPC<sub>6</sub>). |
| first_indexed | 2024-03-10T17:34:50Z |
| format | Article |
| id | doaj.art-3d00289132714f26b1320640724abc65 |
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| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T17:34:50Z |
| publishDate | 2020-08-01 |
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| series | Polymers |
| spelling | doaj.art-3d00289132714f26b1320640724abc652023-11-20T09:53:47ZengMDPI AGPolymers2073-43602020-08-01128180810.3390/polym12081808Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in WaterThi Lien Nguyen0Yuuki Kawata1Kazuhiko Ishihara2Shin-ichi Yusa3Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, JapanDepartment of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, JapanDepartment of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, JapanDepartment of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, JapanBiocompatible amphiphilic statistical copolymers P(MEA/MPC<i><sub>m</sub></i>) composed of 2-methoxyethyl acrylate (MEA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared with three different mol% of the hydrophilic unit MPC (<i>m</i> = 6, 12 and 46 mol%). The monomer reactivity ratios of MEA (<i>r</i><sub>MEA</sub>) and MPC (<i>r</i><sub>MPC</sub>) were 0.53 and 2.21, respectively. The <i>r</i><sub>MEA</sub> × <i>r</i><sub>MPC</sub> value of 1.17 demonstrated that statistical copolymerization was successful. P(MEA/MPC<sub>12</sub>) and P(MEA/MPC<sub>46</sub>) copolymers did not undergo aggregation in water, whereas the P(MEA/MPC<sub>6</sub>) copolymer formed micelles in water with a hydrodynamic radius (<i>R</i><sub>h</sub>) of 96.9 nm and a critical aggregation concentration, which was determined using pyrene fluorescence, at 0.0082 g/L. The restricted motion of the protons in the hydrophobic MEA units in the micelles’ cores provided additional evidence of self-association in P(MEA/MPC<sub>6</sub>).https://www.mdpi.com/2073-4360/12/8/1808statistical copolymer2-methoxyethyl acrylate2-methacryloyloxyethyl phosphorylcholineself-association behavior |
| spellingShingle | Thi Lien Nguyen Yuuki Kawata Kazuhiko Ishihara Shin-ichi Yusa Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water Polymers statistical copolymer 2-methoxyethyl acrylate 2-methacryloyloxyethyl phosphorylcholine self-association behavior |
| title | Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water |
| title_full | Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water |
| title_fullStr | Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water |
| title_full_unstemmed | Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water |
| title_short | Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water |
| title_sort | synthesis of amphiphilic statistical copolymers bearing methoxyethyl and phosphorylcholine groups and their self association behavior in water |
| topic | statistical copolymer 2-methoxyethyl acrylate 2-methacryloyloxyethyl phosphorylcholine self-association behavior |
| url | https://www.mdpi.com/2073-4360/12/8/1808 |
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