Small Heterodimer Partner and Innate Immune Regulation
The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose and cholesterol metabolism. Recent studies repor...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2016-03-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-17.pdf |
| _version_ | 1818357298223906816 |
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| author | Jae-Min Yuk Hyo Sun Jin Eun-Kyeong Jo |
| author_facet | Jae-Min Yuk Hyo Sun Jin Eun-Kyeong Jo |
| author_sort | Jae-Min Yuk |
| collection | DOAJ |
| description | The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose and cholesterol metabolism. Recent studies reported a previously unidentified role for SHP in the regulation of innate immunity and inflammation. The innate immune system has a critical function in the initial response against a variety of microbial and danger signals. Activation of the innate immune response results in the induction of inflammatory cytokines and chemokines to promote anti-microbial effects. An excessive or uncontrolled inflammatory response is potentially harmful to the host, and can cause tissue damage or pathological threat. Therefore, the innate immune response should be tightly regulated to enhance host defense while preventing unwanted immune pathologic responses. In this review, we discuss recent studies showing that SHP is involved in the negative regulation of toll-like receptor-induced and NLRP3 (NACHT, LRR and PYD domains-containing protein 3)-mediated inflammatory responses in innate immune cells. Understanding the function of SHP in innate immune cells will allow us to prevent or modulate acute and chronic inflammation processes in cases where dysregulated innate immune activation results in damage to normal tissues. |
| first_indexed | 2024-12-13T20:10:53Z |
| format | Article |
| id | doaj.art-3d010c43e49a4e438341f923eaaf5be9 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-13T20:10:53Z |
| publishDate | 2016-03-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-3d010c43e49a4e438341f923eaaf5be92022-12-21T23:32:54ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782016-03-01311172410.3803/EnM.2016.31.1.1720207Small Heterodimer Partner and Innate Immune RegulationJae-Min YukHyo Sun JinEun-Kyeong JoThe nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose and cholesterol metabolism. Recent studies reported a previously unidentified role for SHP in the regulation of innate immunity and inflammation. The innate immune system has a critical function in the initial response against a variety of microbial and danger signals. Activation of the innate immune response results in the induction of inflammatory cytokines and chemokines to promote anti-microbial effects. An excessive or uncontrolled inflammatory response is potentially harmful to the host, and can cause tissue damage or pathological threat. Therefore, the innate immune response should be tightly regulated to enhance host defense while preventing unwanted immune pathologic responses. In this review, we discuss recent studies showing that SHP is involved in the negative regulation of toll-like receptor-induced and NLRP3 (NACHT, LRR and PYD domains-containing protein 3)-mediated inflammatory responses in innate immune cells. Understanding the function of SHP in innate immune cells will allow us to prevent or modulate acute and chronic inflammation processes in cases where dysregulated innate immune activation results in damage to normal tissues.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-17.pdfSHP orphan nuclear receptorImmunity, innateSocial control, formalInflammationToll-like receptorsInflammasomes |
| spellingShingle | Jae-Min Yuk Hyo Sun Jin Eun-Kyeong Jo Small Heterodimer Partner and Innate Immune Regulation Endocrinology and Metabolism SHP orphan nuclear receptor Immunity, innate Social control, formal Inflammation Toll-like receptors Inflammasomes |
| title | Small Heterodimer Partner and Innate Immune Regulation |
| title_full | Small Heterodimer Partner and Innate Immune Regulation |
| title_fullStr | Small Heterodimer Partner and Innate Immune Regulation |
| title_full_unstemmed | Small Heterodimer Partner and Innate Immune Regulation |
| title_short | Small Heterodimer Partner and Innate Immune Regulation |
| title_sort | small heterodimer partner and innate immune regulation |
| topic | SHP orphan nuclear receptor Immunity, innate Social control, formal Inflammation Toll-like receptors Inflammasomes |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-17.pdf |
| work_keys_str_mv | AT jaeminyuk smallheterodimerpartnerandinnateimmuneregulation AT hyosunjin smallheterodimerpartnerandinnateimmuneregulation AT eunkyeongjo smallheterodimerpartnerandinnateimmuneregulation |