Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients
Abstract Aim The present study aimed to determine the folic acid supplement (FAS) effects on serum homocysteine and sortilin levels, glycemic indices, and lipid profile in type II diabetic patients. Method A double-blind randomized controlled clinical trial have been performed on 100 patients with T...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-06-01
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| Series: | Nutrition & Diabetes |
| Online Access: | https://doi.org/10.1038/s41387-022-00210-6 |
| _version_ | 1818249816557223936 |
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| author | Noha M. El-khodary Hossam Dabees Rehab H. Werida |
| author_facet | Noha M. El-khodary Hossam Dabees Rehab H. Werida |
| author_sort | Noha M. El-khodary |
| collection | DOAJ |
| description | Abstract Aim The present study aimed to determine the folic acid supplement (FAS) effects on serum homocysteine and sortilin levels, glycemic indices, and lipid profile in type II diabetic patients. Method A double-blind randomized controlled clinical trial have been performed on 100 patients with T2DM randomly divided into two groups that received either placebo or folic acid 5 mg/d for 12 weeks. Results FAS caused a significant decrease in homocysteine and sortilin serum levels (28.2% and 33.7%, P < 0.0001, respectively). After 3 months of intervention, 8.7% decrease in fasting blood glucose (P = 0.0005), 8.2% in HbA1c (P = 0.0002), 13.7% in serum insulin (P < 0.0001) and 21.7% in insulin resistance (P < 0.0001) were found in the folic acid group, however no significant difference was observed in the placebo group. Serum hs-CRP level showed significant positive associations with sortilin (r = 0.237, P = 0.018), homocysteine (r = 0.308, P = 0.002) and fasting blood glucose (r = 0.342, P = 0.000). There were no significant changes in lipid profile in both groups after 12 weeks. Conclusion FAS might be beneficial for reducing homocysteine and sortilin levels, enhancing glycemic control, and improved insulin resistance in patients with T2DM. |
| first_indexed | 2024-12-12T15:42:30Z |
| format | Article |
| id | doaj.art-3d01375c1dad409dbfb743ff03280558 |
| institution | Directory Open Access Journal |
| issn | 2044-4052 |
| language | English |
| last_indexed | 2024-12-12T15:42:30Z |
| publishDate | 2022-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Nutrition & Diabetes |
| spelling | doaj.art-3d01375c1dad409dbfb743ff032805582022-12-22T00:19:52ZengNature Publishing GroupNutrition & Diabetes2044-40522022-06-011211810.1038/s41387-022-00210-6Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patientsNoha M. El-khodary0Hossam Dabees1Rehab H. Werida2Clinical Pharmacy Department, Faculty of Pharmacy, Kafrelsheikh UniversityInternal Medicine and Diabetes Department, Damanhour Medical National InstituteClinical Pharmacy & Pharmacy Practice Department, Faculty of Pharmacy, Damanhour UniversityAbstract Aim The present study aimed to determine the folic acid supplement (FAS) effects on serum homocysteine and sortilin levels, glycemic indices, and lipid profile in type II diabetic patients. Method A double-blind randomized controlled clinical trial have been performed on 100 patients with T2DM randomly divided into two groups that received either placebo or folic acid 5 mg/d for 12 weeks. Results FAS caused a significant decrease in homocysteine and sortilin serum levels (28.2% and 33.7%, P < 0.0001, respectively). After 3 months of intervention, 8.7% decrease in fasting blood glucose (P = 0.0005), 8.2% in HbA1c (P = 0.0002), 13.7% in serum insulin (P < 0.0001) and 21.7% in insulin resistance (P < 0.0001) were found in the folic acid group, however no significant difference was observed in the placebo group. Serum hs-CRP level showed significant positive associations with sortilin (r = 0.237, P = 0.018), homocysteine (r = 0.308, P = 0.002) and fasting blood glucose (r = 0.342, P = 0.000). There were no significant changes in lipid profile in both groups after 12 weeks. Conclusion FAS might be beneficial for reducing homocysteine and sortilin levels, enhancing glycemic control, and improved insulin resistance in patients with T2DM.https://doi.org/10.1038/s41387-022-00210-6 |
| spellingShingle | Noha M. El-khodary Hossam Dabees Rehab H. Werida Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients Nutrition & Diabetes |
| title | Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients |
| title_full | Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients |
| title_fullStr | Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients |
| title_full_unstemmed | Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients |
| title_short | Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients |
| title_sort | folic acid effect on homocysteine sortilin levels and glycemic control in type 2 diabetes mellitus patients |
| url | https://doi.org/10.1038/s41387-022-00210-6 |
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