| Summary: | The objective of this study was to evaluate the influence of the Limosilactobacillus reuteri ID-D01 (ID-D01) lactic acid bacteria probiotic on exercise performance and muscle fatigue in C57BL/6 mice. ID-D01 improved exercise endurance by extending treadmill running time and forced swimming duration. Moreover, mice treated with ID-D01 exhibited increased quadriceps muscle tissue weight, suggesting a potential for enhancing muscle growth. Serum analysis showed decreased muscle fatigue markers, and lower levels of lactate, and ammonia, indicating reduced exercise-induced fatigue. ID-D01 also affected intramuscular factors such as citrate synthase and glycogen. Notably, citrate synthase levels increased, indicating improved aerobic capacity, while intramuscular glycogen decreased. ID-D01 decreased reactive oxygen species and increased antioxidant enzymes SOD2 and catalase, in muscle tissue. This study identifies the potential of ID-D01 to improve exercise performance and relieve muscle fatigue. Further, it provides a rationale for the development of ID-D01-based functional supplements for individuals who are physically active.
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