Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain
Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4–8 μg/mL) was...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2009-06-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/15/6/08-0684_article |
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| author | Adela G. de la Campa Carmen Ardanuy Luz Balsalobre Emilio Pérez-Trallero Jose M. Marimón Asunción Fenoll Josefina Liñares |
| author_facet | Adela G. de la Campa Carmen Ardanuy Luz Balsalobre Emilio Pérez-Trallero Jose M. Marimón Asunción Fenoll Josefina Liñares |
| author_sort | Adela G. de la Campa |
| collection | DOAJ |
| description | Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4–8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC ≥16 μg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733) appeared in 2006. |
| first_indexed | 2024-12-12T18:50:47Z |
| format | Article |
| id | doaj.art-3d08b429b9754abb808aa84f696bf4fc |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T18:50:47Z |
| publishDate | 2009-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-3d08b429b9754abb808aa84f696bf4fc2022-12-22T00:15:23ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592009-06-0115690591110.3201/eid1506.080684Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, SpainAdela G. de la CampaCarmen ArdanuyLuz BalsalobreEmilio Pérez-TralleroJose M. MarimónAsunción FenollJosefina LiñaresAmong 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4–8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC ≥16 μg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733) appeared in 2006.https://wwwnc.cdc.gov/eid/article/15/6/08-0684_articleStreptococcus pneumoniaestreptococciDNA topoisomerasesfluoroquinolonesciprofloxacinantimicrobial resistance |
| spellingShingle | Adela G. de la Campa Carmen Ardanuy Luz Balsalobre Emilio Pérez-Trallero Jose M. Marimón Asunción Fenoll Josefina Liñares Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain Emerging Infectious Diseases Streptococcus pneumoniae streptococci DNA topoisomerases fluoroquinolones ciprofloxacin antimicrobial resistance |
| title | Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain |
| title_full | Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain |
| title_fullStr | Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain |
| title_full_unstemmed | Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain |
| title_short | Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain |
| title_sort | changes in fluoroquinolone resistant streptococcus pneumonia after 7 valent conjugate vaccination spain |
| topic | Streptococcus pneumoniae streptococci DNA topoisomerases fluoroquinolones ciprofloxacin antimicrobial resistance |
| url | https://wwwnc.cdc.gov/eid/article/15/6/08-0684_article |
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