Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center
Objectives:To investigate the demographic, etiologic, and clinical features of HLA-B27-associated uveitis.Materials and Methods:The clinical records of 91 patients diagnosed with HLA-B27-associated uveitis at the Ulucanlar Eye Training and Research Hospital between the years of 2005 and 2016 were re...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2019-02-01
|
| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/etiological-and-clinical-characteristics-of-hla-b2/25477
|
| _version_ | 1797922512948953088 |
|---|---|
| author | Merve İnanç Mert Şimşek Müge Pınar Çakar Özdal |
| author_facet | Merve İnanç Mert Şimşek Müge Pınar Çakar Özdal |
| author_sort | Merve İnanç |
| collection | DOAJ |
| description | Objectives:To investigate the demographic, etiologic, and clinical features of HLA-B27-associated uveitis.Materials and Methods:The clinical records of 91 patients diagnosed with HLA-B27-associated uveitis at the Ulucanlar Eye Training and Research Hospital between the years of 2005 and 2016 were reviewed. Each patient’s presenting complaints, best-corrected visual acuities in first and last visits, biomicroscopic and fundoscopic examination findings, frequency and seasonal distribution of attacks, and demographic data such as age and sex were noted. Therapeutic approaches, duration of follow-up, and complications were analyzed.Results:A total of 91 patients (179 eyes) aged 19-82 years (mean age 46.52±13.06 years) were included. Forty-three patients (47.3%) were female and 48 (52.7%) were male. Bilateral involvement was observed in 44 (48.4%) and unilateral involvement was observed in 47 (51.6%) patients. The most frequent complaint was redness (67%), followed by decreased and/or blurred vision (50.5%). The mean follow-up time was 38.2 months (range, 1-245 months). Anterior uveitis was most common anatomical subtype, seen in 86 (94.5%) of the patients. Mean number of attacks was 1.93±1.45 per patient-year and a significantly higher number of uveitis attacks (47%) occurred in winter. Twenty-four patients (26.3%) were diagnosed with ankylosing spondylitis. Fibrinous uveitis was detected in 36 patients (39.5%). Posterior synechia developed in 41 (22.9%) and hypopyon developed in 7 (3.9%) eyes. The most common complications were cataract (n=12, 6.7%) and ocular hypertension (n=15, 8.3%).Conclusion:Ninety-one (6.3%) of the 1422 patients followed in our uvea clinic were diagnosed with HLA-B27-associated uveitis. HLA-B27-associated uveitis is characterized by acute, recurring sudden-onset iridocyclitis with a moderate to severe amount of fibrin and cells in the anterior chamber, and is easily treatable. Visual prognosis is good despite the complications. |
| first_indexed | 2024-04-10T14:32:37Z |
| format | Article |
| id | doaj.art-3d08bf931aae4a41b37dd8f986f6a9f6 |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T14:32:37Z |
| publishDate | 2019-02-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-3d08bf931aae4a41b37dd8f986f6a9f62023-02-15T16:08:43ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612019-02-01491101410.4274/tjo.galenos.2018.5389613049054Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral CenterMerve İnanç0Mert Şimşek1Müge Pınar Çakar Özdal2 Erciş Devlet Hastanesi, Göz Hastalıkları Kliniği, Van, Türkiye Ulucanlar Göz Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, Ankara, Türkiye Ulucanlar Göz Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, Ankara, Türkiye Objectives:To investigate the demographic, etiologic, and clinical features of HLA-B27-associated uveitis.Materials and Methods:The clinical records of 91 patients diagnosed with HLA-B27-associated uveitis at the Ulucanlar Eye Training and Research Hospital between the years of 2005 and 2016 were reviewed. Each patient’s presenting complaints, best-corrected visual acuities in first and last visits, biomicroscopic and fundoscopic examination findings, frequency and seasonal distribution of attacks, and demographic data such as age and sex were noted. Therapeutic approaches, duration of follow-up, and complications were analyzed.Results:A total of 91 patients (179 eyes) aged 19-82 years (mean age 46.52±13.06 years) were included. Forty-three patients (47.3%) were female and 48 (52.7%) were male. Bilateral involvement was observed in 44 (48.4%) and unilateral involvement was observed in 47 (51.6%) patients. The most frequent complaint was redness (67%), followed by decreased and/or blurred vision (50.5%). The mean follow-up time was 38.2 months (range, 1-245 months). Anterior uveitis was most common anatomical subtype, seen in 86 (94.5%) of the patients. Mean number of attacks was 1.93±1.45 per patient-year and a significantly higher number of uveitis attacks (47%) occurred in winter. Twenty-four patients (26.3%) were diagnosed with ankylosing spondylitis. Fibrinous uveitis was detected in 36 patients (39.5%). Posterior synechia developed in 41 (22.9%) and hypopyon developed in 7 (3.9%) eyes. The most common complications were cataract (n=12, 6.7%) and ocular hypertension (n=15, 8.3%).Conclusion:Ninety-one (6.3%) of the 1422 patients followed in our uvea clinic were diagnosed with HLA-B27-associated uveitis. HLA-B27-associated uveitis is characterized by acute, recurring sudden-onset iridocyclitis with a moderate to severe amount of fibrin and cells in the anterior chamber, and is easily treatable. Visual prognosis is good despite the complications. http://www.oftalmoloji.org/archives/archive-detail/article-preview/etiological-and-clinical-characteristics-of-hla-b2/25477 HLA-B27uveitisankylosing spondylitisdemographyetiology |
| spellingShingle | Merve İnanç Mert Şimşek Müge Pınar Çakar Özdal Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center Türk Oftalmoloji Dergisi HLA-B27 uveitis ankylosing spondylitis demography etiology |
| title | Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center |
| title_full | Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center |
| title_fullStr | Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center |
| title_full_unstemmed | Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center |
| title_short | Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center |
| title_sort | etiological and clinical characteristics of hla b27 associated uveitis in a tertiary referral center |
| topic | HLA-B27 uveitis ankylosing spondylitis demography etiology |
| url |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/etiological-and-clinical-characteristics-of-hla-b2/25477
|
| work_keys_str_mv | AT merveinanc etiologicalandclinicalcharacteristicsofhlab27associateduveitisinatertiaryreferralcenter AT mertsimsek etiologicalandclinicalcharacteristicsofhlab27associateduveitisinatertiaryreferralcenter AT mugepınarcakarozdal etiologicalandclinicalcharacteristicsofhlab27associateduveitisinatertiaryreferralcenter |