Composition and Anti-ulcer Activity of the Essential Oil from Citri Reticulatae Pericarpium in Rodents
Abstract The essential oil from Citri Reticulatae Pericarpium (EOC) was analyzed by GC/MS. The major component of EOC was found to be d-limonene (92.3% of the total essential oil). Anti-ulcer and antioxidant activities of EOC were evaluated in several gastric ulcer models. The ulcer index or area an...
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| Format: | Article |
| Language: | English |
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Instituto de Tecnologia do Paraná (Tecpar)
2023-02-01
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| Series: | Brazilian Archives of Biology and Technology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100412&lng=en&tlng=en |
| _version_ | 1811164845036273664 |
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| author | Qingyao Li Ting Lu Xiaoyan Chen Hongbiao Chu |
| author_facet | Qingyao Li Ting Lu Xiaoyan Chen Hongbiao Chu |
| author_sort | Qingyao Li |
| collection | DOAJ |
| description | Abstract The essential oil from Citri Reticulatae Pericarpium (EOC) was analyzed by GC/MS. The major component of EOC was found to be d-limonene (92.3% of the total essential oil). Anti-ulcer and antioxidant activities of EOC were evaluated in several gastric ulcer models. The ulcer index or area and biochemical markers of superoxide dismutase (SOD) and malondialdehyde (MDA) were determined. EOC significantly inhibited gastric mucosal lesions induced by ulcerogenic agents with an inhibitory rate of nearly 50% at an oral dose of 85 mg/kg, and exerted a healing effect on acetic acid-induced ulcers with a curative rate of 63%. HCl/EtOH administration caused severe oxidative stress and lipid peroxidation, which was confirmed by significantly decreased SOD activity and increased MDA levels in mice gastric tissues. EOC pretreatment significantly increased SOD activity and decreased MDA levels, indicating that EOC protects the gastric mucosa against development of numerous lesions by inhibiting oxidative stress. These results demonstrate that EOC has anti-ulcerogenic activity and the mechanism underlying its gastric protective effect is associated with its antioxidant properties. |
| first_indexed | 2024-04-10T15:27:49Z |
| format | Article |
| id | doaj.art-3d0ab57a91ea4c14b2365e98e5184534 |
| institution | Directory Open Access Journal |
| issn | 1678-4324 |
| language | English |
| last_indexed | 2024-04-10T15:27:49Z |
| publishDate | 2023-02-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-3d0ab57a91ea4c14b2365e98e51845342023-02-14T07:33:34ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242023-02-016610.1590/1678-4324-2023210786Composition and Anti-ulcer Activity of the Essential Oil from Citri Reticulatae Pericarpium in RodentsQingyao Lihttps://orcid.org/0000-0002-0440-0015Ting Luhttps://orcid.org/0000-0002-4140-1623Xiaoyan Chenhttps://orcid.org/0000-0003-1794-9725Hongbiao Chuhttps://orcid.org/0000-0002-6233-9646Abstract The essential oil from Citri Reticulatae Pericarpium (EOC) was analyzed by GC/MS. The major component of EOC was found to be d-limonene (92.3% of the total essential oil). Anti-ulcer and antioxidant activities of EOC were evaluated in several gastric ulcer models. The ulcer index or area and biochemical markers of superoxide dismutase (SOD) and malondialdehyde (MDA) were determined. EOC significantly inhibited gastric mucosal lesions induced by ulcerogenic agents with an inhibitory rate of nearly 50% at an oral dose of 85 mg/kg, and exerted a healing effect on acetic acid-induced ulcers with a curative rate of 63%. HCl/EtOH administration caused severe oxidative stress and lipid peroxidation, which was confirmed by significantly decreased SOD activity and increased MDA levels in mice gastric tissues. EOC pretreatment significantly increased SOD activity and decreased MDA levels, indicating that EOC protects the gastric mucosa against development of numerous lesions by inhibiting oxidative stress. These results demonstrate that EOC has anti-ulcerogenic activity and the mechanism underlying its gastric protective effect is associated with its antioxidant properties.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100412&lng=en&tlng=enCitri Reticulatae Pericarpiumessential oil compositiond-limonenegastric ulcerantioxidant. |
| spellingShingle | Qingyao Li Ting Lu Xiaoyan Chen Hongbiao Chu Composition and Anti-ulcer Activity of the Essential Oil from Citri Reticulatae Pericarpium in Rodents Brazilian Archives of Biology and Technology Citri Reticulatae Pericarpium essential oil composition d-limonene gastric ulcer antioxidant. |
| title | Composition and Anti-ulcer Activity of the Essential Oil from Citri Reticulatae Pericarpium in Rodents |
| title_full | Composition and Anti-ulcer Activity of the Essential Oil from Citri Reticulatae Pericarpium in Rodents |
| title_fullStr | Composition and Anti-ulcer Activity of the Essential Oil from Citri Reticulatae Pericarpium in Rodents |
| title_full_unstemmed | Composition and Anti-ulcer Activity of the Essential Oil from Citri Reticulatae Pericarpium in Rodents |
| title_short | Composition and Anti-ulcer Activity of the Essential Oil from Citri Reticulatae Pericarpium in Rodents |
| title_sort | composition and anti ulcer activity of the essential oil from citri reticulatae pericarpium in rodents |
| topic | Citri Reticulatae Pericarpium essential oil composition d-limonene gastric ulcer antioxidant. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100412&lng=en&tlng=en |
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