Quantification of bergenin, antioxidant activity and nitric oxide inhibition from bark, leaf and twig of Endopleura uchi
Phytochemical investigation of Endopleura uchi led to the isolation of a gallic acid derivate, known as bergenin (2) and friedelin (1), a pentacyclic triterpene. The present work also reports the bergenin quantification in different Endopleura uchi bark, twig and leaves extracts. Our findings showed...
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| Format: | Article |
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Sociedade Brasileira de Química
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| Series: | Química Nova |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000400413&lng=en&tlng=en |
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| author | Magno P. Muniz Sergio M. Nunomura Emerson S. Lima Arleilson S. Lima Patrícia D. O. de Almeida Rita C. S. Nunomura |
| author_facet | Magno P. Muniz Sergio M. Nunomura Emerson S. Lima Arleilson S. Lima Patrícia D. O. de Almeida Rita C. S. Nunomura |
| author_sort | Magno P. Muniz |
| collection | DOAJ |
| description | Phytochemical investigation of Endopleura uchi led to the isolation of a gallic acid derivate, known as bergenin (2) and friedelin (1), a pentacyclic triterpene. The present work also reports the bergenin quantification in different Endopleura uchi bark, twig and leaves extracts. Our findings showed the highest bergenin concentration in bark methanol extracts (4.75%) and the lowest concentration in twig aqueous extracts (1.89%). Phenolics quantification by Folin-Ciocalteu, revealed phenolic compounds level values from 16.69 to 43.02 mg GAE g-1 dry extract. The ferric reducing antioxidant activity ranged from 230.43 to 567.89 mmol Fe+2 g-1 dry extract. DPPH IC50 free radicals showed to range from 12.04 to 24.20 μg mL-1. Leaves’ chloroform fraction exhibited the highest nitric oxide inhibiting activity bearing IC50= 3.2 μg mL-1. Results show this species to hold significant bergenin concentrations as well as phenolic and anti-inflammatory compounds in all extracts suggesting it bear therapeutic potential. |
| first_indexed | 2024-12-13T11:48:20Z |
| format | Article |
| id | doaj.art-3d0adb13af5143d8a8583784c730c18b |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-13T11:48:20Z |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-3d0adb13af5143d8a8583784c730c18b2022-12-21T23:47:26ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-706443441341810.21577/0100-4042.20170514S0100-40422020000400413Quantification of bergenin, antioxidant activity and nitric oxide inhibition from bark, leaf and twig of Endopleura uchiMagno P. MunizSergio M. NunomuraEmerson S. LimaArleilson S. LimaPatrícia D. O. de AlmeidaRita C. S. NunomuraPhytochemical investigation of Endopleura uchi led to the isolation of a gallic acid derivate, known as bergenin (2) and friedelin (1), a pentacyclic triterpene. The present work also reports the bergenin quantification in different Endopleura uchi bark, twig and leaves extracts. Our findings showed the highest bergenin concentration in bark methanol extracts (4.75%) and the lowest concentration in twig aqueous extracts (1.89%). Phenolics quantification by Folin-Ciocalteu, revealed phenolic compounds level values from 16.69 to 43.02 mg GAE g-1 dry extract. The ferric reducing antioxidant activity ranged from 230.43 to 567.89 mmol Fe+2 g-1 dry extract. DPPH IC50 free radicals showed to range from 12.04 to 24.20 μg mL-1. Leaves’ chloroform fraction exhibited the highest nitric oxide inhibiting activity bearing IC50= 3.2 μg mL-1. Results show this species to hold significant bergenin concentrations as well as phenolic and anti-inflammatory compounds in all extracts suggesting it bear therapeutic potential.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000400413&lng=en&tlng=enhumiriaceaeliquid chromatographyanti-inflammatory agentsnatural productsdpph |
| spellingShingle | Magno P. Muniz Sergio M. Nunomura Emerson S. Lima Arleilson S. Lima Patrícia D. O. de Almeida Rita C. S. Nunomura Quantification of bergenin, antioxidant activity and nitric oxide inhibition from bark, leaf and twig of Endopleura uchi Química Nova humiriaceae liquid chromatography anti-inflammatory agents natural products dpph |
| title | Quantification of bergenin, antioxidant activity and nitric oxide inhibition from bark, leaf and twig of Endopleura uchi |
| title_full | Quantification of bergenin, antioxidant activity and nitric oxide inhibition from bark, leaf and twig of Endopleura uchi |
| title_fullStr | Quantification of bergenin, antioxidant activity and nitric oxide inhibition from bark, leaf and twig of Endopleura uchi |
| title_full_unstemmed | Quantification of bergenin, antioxidant activity and nitric oxide inhibition from bark, leaf and twig of Endopleura uchi |
| title_short | Quantification of bergenin, antioxidant activity and nitric oxide inhibition from bark, leaf and twig of Endopleura uchi |
| title_sort | quantification of bergenin antioxidant activity and nitric oxide inhibition from bark leaf and twig of endopleura uchi |
| topic | humiriaceae liquid chromatography anti-inflammatory agents natural products dpph |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000400413&lng=en&tlng=en |
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